Evidence map›Paper›PMID 26080701›Full record

ReviewNanomedicine (London, England)2015

Molecular imaging of atherosclerosis with nanoparticle-based fluorinated MRI contrast agents.

Rohun U Palekar, Andrew P Jallouk, Gregory M Lanza, Hua Pan, Samuel A Wickline

Abstract readReview
In one paragraph

Review in Nanomedicine (London, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Article
  2. Review
  3. Photodynamic Therapy for Atherosclerosis.International journal of molecular sciences · 2024
    Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Review
  15. Article
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  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rohun U PalekarDepartment of Biomedical Engineering, Washington University, Whitaker Hall, Campus Box 1097, One Brookings Drive, St. Louis, MO 63130, USA.
Andrew P JalloukDepartment of Medicine, Washington University, Campus Box 8215, 4320 Forest Park Avenue, St Louis, MO 63108, USA.
Gregory M LanzaDepartment of Biomedical Engineering, Washington University, Whitaker Hall, Campus Box 1097, One Brookings Drive, St. Louis, MO 63130, USA.
Hua PanDepartment of Medicine, Washington University, Campus Box 8215, 4320 Forest Park Avenue, St Louis, MO 63108, USA.
Samuel A WicklineDepartment of Biomedical Engineering, Washington University, Whitaker Hall, Campus Box 1097, One Brookings Drive, St. Louis, MO 63130, USA.

Funding

METHODS IN MOLECULAR IMAGING AND TARGETED THERAPEUTICSR01HL073646 · NHLBI · WASHINGTON UNIVERSITY · PI WICKLINE, SAMUEL A · 2004 to 2016
$13.7M
Translational Research Skills Development CoreU54HL112303 · NHLBI · WASHINGTON UNIVERSITY · PI SADLER, J EVAN · 2012 to 2016
$8.8M
Theranostic Approach to Asthma Using Anti-Angiogenic NanomedicineR01HL113392 · NHLBI · WASHINGTON UNIVERSITY · PI LANZA, GREGORY M, WAGNER, ELIZABETH · 2012 to 2016
$3.3M
NEXT GENERATION APPROACHES TO BREAST CANCER USING IMAGE GUIDED DRUG DELIVERYR01CA154737 · NCI · WASHINGTON UNIVERSITY · PI LANZA, GREGORY M, PAN, DIPANJAN · 2011 to 2015
$2.4M
Prevention and Treatment of Acute Kidney InjuryR01DK102691 · NIDDK · WASHINGTON UNIVERSITY · PI WICKLINE, SAMUEL A · 2015 to 2018
$2.0M
THERAPY NANOPARTICLES FOR MODULATION OF INFLAMMATION IN NEUROMUSCULAR DISEASER01AR056223 · NIAMS · WASHINGTON UNIVERSITY · PI WICKLINE, SAMUEL A · 2009 to 2013
$1.6M
QUANTIFYING KIDNEY INJURY AND INFLAMMATION WITH FLUORINE (19F) MRIR21DK095555 · NIDDK · WASHINGTON UNIVERSITY · PI WICKLINE, SAMUEL A · 2012 to 2013
$411k
NCI NIH HHS R01 CA154737NHLBI NIH HHS HL073646NHLBI NIH HHS HL112303NHLBI NIH HHS R01 HL073646NHLBI NIH HHS R01 HL113392NHLBI NIH HHS U54 HL112303NIAMS NIH HHS AR056223NIAMS NIH HHS R01 AR056223NIDDK NIH HHS DK095555NIDDK NIH HHS R01 DK102691NIDDK NIH HHS R21 DK095555
6 · The paper itself

Abstract

As atherosclerosis remains one of the most prevalent causes of patient mortality, the ability to diagnose early signs of plaque rupture and thrombosis represents a significant clinical need. With recent advances in nanotechnology, it is now possible to image specific molecular processes noninvasively with MRI, using various types of nanoparticles as contrast agents. In the context of cardiovascular disease, it is possible to specifically deliver contrast agents to an epitope of interest for detecting vascular inflammatory processes, which serve as predecessors to atherosclerotic plaque development. Herein, we review various applications of nanotechnology in detecting atherosclerosis using MRI, with an emphasis on perfluorocarbon nanoparticles and fluorine imaging, along with theranostic prospects of nanotechnology in cardiovascular disease.

Indexed as

AtherosclerosisContrast MediaHumansMagnetic Resonance ImagingMolecular ImagingNanoparticlesPlaque, AtheroscleroticRadiographyContrast Mediaatherosclerosiscontrast agentinflammationtheranosticsthrombosis

Identifiers

PMID26080701
PMCPMC4483172

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.