ArticleProceedings of the National Academy of Sciences of the United States of America2015
Self-repairing symmetry in jellyfish through mechanically driven reorganization.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 84 citations in OpenAlex.
- Single-cell analyses of tissue regeneration in two true jellyfish.Molecular biology and evolution · 2026Article
- Jellyfish-Inspired Ultrafast and Versatile Magnetic Soft Robots for Biomedical Applications.Cyborg and bionic systems (Washington, D.C.) · 2026Article
- Microbiome modulation in regeneration in jellyfish.PloS one · 2026Article
- Investigating the evolution and features of regeneration using cnidarians.Integrative and comparative biology · 2025Review
- Sleeping upside-down: Knockdown of a sleep-associated gene induces daytime sleep in the jellyfishProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Jellyfish shape as a mechanical balance.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Physical Forces in Regeneration of Cells and Tissues.Cold Spring Harbor perspectives in biology · 2025Review
- Regeneration and Musculature in HalvedIntegrative organismal biology (Oxford, England) · 2025Article
- Jellyfish for the study of nervous system evolution and function.Current opinion in neurobiology · 2024Review
- Photochemically Induced Propulsion of a 4D Printed Liquid Crystal Elastomer Biomimetic Swimmer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Buffering Mechanism in Aortic Arch Artery Formation and Congenital Heart Disease.Circulation research · 2024Article
- Nonlinear elasticity and short-range mechanical coupling govern the rate and symmetry of mouth opening inProceedings. Biological sciences · 2024Article
- The microbiome of a Pacific moon jellyfish Aurelia coerulea.PloS one · 2024Article
- In vivo neuromodulation of animal behavior with organic semiconducting oligomers.Science advances · 2023Article
- From Nature to Technology: Exploring Bioinspired Polymer Actuators via Electrospinning.Polymers · 2023Review
- Integrative biology of injury in animals.Biological reviews of the Cambridge Philosophical Society · 2023Review
- Reproducible propagation technique for the symbiotic cnidarian model system Cassiopea xamachana.Biology open · 2022Article
- Article
- A pan-metazoan concept for adult stem cells: the wobbling Penrose landscape.Biological reviews of the Cambridge Philosophical Society · 2022Article
- Genome of the sea anemoneFrontiers in cell and developmental biology · 2022Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
What happens when an animal is injured and loses important structures? Some animals simply heal the wound, whereas others are able to regenerate lost parts. In this study, we report a previously unidentified strategy of self-repair, where moon jellyfish respond to injuries by reorganizing existing parts, and rebuilding essential body symmetry, without regenerating what is lost. Specifically, in response to arm amputation, the young jellyfish of Aurelia aurita rearrange their remaining arms, recenter their manubria, and rebuild their muscular networks, all completed within 12 hours to 4 days. We call this process symmetrization. We find that symmetrization is not driven by external cues, cell proliferation, cell death, and proceeded even when foreign arms were grafted on. Instead, we find that forces generated by the muscular network are essential. Inhibiting pulsation using muscle relaxants completely, and reversibly, blocked symmetrization. Furthermore, we observed that decreasing pulse frequency using muscle relaxants slowed symmetrization, whereas increasing pulse frequency by lowering the magnesium concentration in seawater accelerated symmetrization. A mathematical model that describes the compressive forces from the muscle contraction, within the context of the elastic response from the mesoglea and the ephyra geometry, can recapitulate the recovery of global symmetry. Thus, self-repair in Aurelia proceeds through the reorganization of existing parts, and is driven by forces generated by its own propulsion machinery. We find evidence for symmetrization across species of jellyfish (Chrysaora pacifica, Mastigias sp., and Cotylorhiza tuberculata).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.