ArticleTranslational psychiatry2015
Telomere length is associated with oppositional defiant behavior and maternal clinical depression in Latino preschool children.
Article in Translational psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Early life adversity and telomere length: a meta-analysis.Molecular psychiatry · 2018Pooled it
- Telomere Length and Emotional and Behavioral Problems in Children from the Prospective Birth Cohort INfancia y Medio Ambiente (INMA) Study.Children (Basel, Switzerland) · 2025Article
- Temperament and sex as moderating factors of the effects of exposure to maternal depression on telomere length in early childhood.Development and psychopathology · 2025Article
- Associations among temperament characteristics and telomere length and attrition rate in early childhood.Developmental psychology · 2024Article
- Reduced SIRT1 and SIRT3 and Lower Antioxidant Capacity of Seminal Plasma Is Associated with Shorter Sperm Telomere Length in Oligospermic Men.International journal of molecular sciences · 2024Article
- Telomere length in early childhood and its association with attention: a study in 4-6 year old children.Frontiers in pediatrics · 2024Article
- Article
- Associations Between Children's Telomere Length, Parental Intrusiveness, and the Development of Early Externalizing Behaviors.Child psychiatry and human development · 2023Article
- Low Magnesium in Conjunction with High Homocysteine and Less Sleep Accelerates Telomere Attrition in Healthy Elderly Australian.International journal of molecular sciences · 2023Article
- Psychosocial Factors and Telomere Length Among Parents and Infants of Immigrant Arab American Families.Biological research for nursing · 2023Article
- Non-Linear and Sex-Specific Effect of Maternal Pre-Pregnancy BMI on Emotional and Behavioral Development of Preschool Children: A Population-Based Cohort Study.International journal of environmental research and public health · 2022Article
- Shortened Infant Telomere Length Is Associated with Attention Deficit/Hyperactivity Disorder Symptoms in Children at Age Two Years: A Birth Cohort Study.International journal of molecular sciences · 2022Article
- The Longitudinal Associations Between Paternal Incarceration and Family Well-Being: Implications for Ethnic/Racial Disparities in Health.Journal of the American Academy of Child and Adolescent Psychiatry · 2022Article
- Prenatal exposure to maternal psychological distress and telomere length in childhood.Developmental psychobiology · 2022Article
- Associations of prenatal maternal stress with measures of cognition in 7.5-month-old infants.Developmental psychobiology · 2021Article
- Telomere Length and ADHD Symptoms in Young Adults.Journal of attention disorders · 2021Article
- Rapid infant weight gain and prenatal maternal depression are associated with prehypertension/hypertension before age 9.Journal of human hypertension · 2020Article
- Telomere Length and Psychopathology: Specificity and Direction of Effects Within the Bucharest Early Intervention Project.Journal of the American Academy of Child and Adolescent Psychiatry · 2020Article
- The future of rodent models in depression research.Nature reviews. Neuroscience · 2019Review
- The association between intimate partner violence against women and newborn telomere length.Translational psychiatry · 2019Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Exposure to psychological stress and depression are associated with shorter white blood cell telomere length (TL) in adults, possibly via associated lifelong oxidative stressors. Exposure to maternal depression increases risk for future depression and behavior problems in children, and Latino youth are at high risk. Few studies have evaluated the role of exposure to maternal depression or child behavior in relation to TL in children. We assessed early-childhood exposures to maternal depression from birth to the age of 5 years and child behavior from ages 3-5 years in a cohort of Latino children in relation to child leukocyte TL at ages 4 and 5 years. Children who had oppositional defiant behavior at 3, 4 or 5 years had shorter TL than those without by ~450 base pairs (P < 0.01). In multivariate analyses, independent predictors for shorter TL at 4 and 5 years of age included oppositional defiant disorder at 3, 4 or 5 years (β = -359.25, 95% CI -633.84 to 84.66; P = 0.01), exposure to maternal clinical depression at 3 years of age (β = -363.99, 95% CI -651.24 to 764.74; P = 0.01), shorter maternal TL (β = 502.92, 95% CI 189.21-816.63) and younger paternal age at the child's birth (β = 24.63, 95% CI 1.14-48.12). Thus, exposure to maternal clinical depression (versus depressive symptoms) in early childhood was associated with deleterious consequences on child cellular health as indicated by shorter TL at 4 and 5 years of age. Similarly, children with oppositional defiant behavior also had shorter TL, possibly related to early exposures to maternal clinical depression. Our study is the first to link maternal clinical depression and oppositional defiant behavior with shorter TL in the preschool years in a relatively homogenous population of low-income Latino children.
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