Evidence map›Paper›PMID 26080092›Full record

SynthesisPloS one2015

Perioperative Blood Transfusion Promotes Worse Outcomes of Bladder Cancer after Radical Cystectomy: A Systematic Review and Meta-Analysis.

You-Lin Wang, Bo Jiang, Fu-Fen Yin, Hao-Qing Shi, Xiao-Dong Xu, Shuai-Shuai Zheng, Shuai Wu, Si-Chuan Hou

Registry-linked trialOpen access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05816668 (Tranexamic Acid's Effects in Patients Undergoing Laparoscopic Radical Prostatectomy), which is not on this map. Cited by 35 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 7 pooled it
9.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05816668 phase3unknown statusnot on this mapstarted 2023, after this paper: background citation

Tranexamic Acid's Effects in Patients Undergoing Laparoscopic Radical Prostatectomy: a Randomized, Double-blind, Placebo-controlled Trial

TypeinterventionalSponsorInstituto do Cancer do Estado de São PauloRan2023 to 2024Enrolled122ConditionsProstate CancerArmsTranexamic acid, Placebo
3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 7 syntheses or guidelines pooled it, 78 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. The PTWorld journal of urology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

You-Lin WangDepartment of Urology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, China.
Bo JiangDepartment of Urology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, China.
Fu-Fen YinDepartment of Obstetrics and Gynecology, Affiliate Hospital of Qingdao University, Qingdao, China.
Hao-Qing ShiDepartment of Urology, Affiliate Hospital of Qingdao University, Qingdao, China.
Xiao-Dong XuDepartment of Urology, Affiliate Hospital of Qingdao University, Qingdao, China.
Shuai-Shuai ZhengDepartment of Urology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, China.
Shuai WuDepartment of Urology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, China.
Si-Chuan HouDepartment of Urology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, China; Department of Urology, Qingdao Municipal Hospital, Dalian Medical University, Dalian, China.
Qingdao University · CNQingdao Municipal Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMultiple studies have investigated the effect of perioperative blood transfusion (PBT) for patients with radical cystectomy (RC), but the results have been inconsistent. We conducted a systematic review and meta-analysis to investigate the relationship between PBT and the clinical outcomes of RC patients.

methodsWe searched MEDLINE, EMBASE, the Cochrane library and BIOSIS previews to identify relevant literature for studies that focused on the relationship of PBT and outcomes of patients undergoing RC. A fixed or random effects model was used in this meta-analysis to calculate the pooled hazard ratio (HR) with 95% confidence intervals (CIs).

resultsA total of 7080 patients in 6 studies matched the selection criteria. Aggregation of the data suggested that PBT in patients who underwent RC correlated with increased all-cause mortality, cancer-specific mortality and cancer recurrence. The combined HRs were 1.19 (n = 6 studies, 95% CI: 1.11-1.27, Z = 4.71, P<0.00001), 1.17 (n = 4 studies, 95% CI: 1.06-1.30, Z = 3.06, P = 0.002), 1.14 (n = 3 studies, 95% CI: 1.03-1.27, Z = 2.50, P = 0.01), respectively. The all-cause mortality associated with PBT did not vary by the characteristics of the study, including number of study participants, follow-up period and the median blood transfusion ratio of the study.

conclusionOur data showed that PBT significantly increased the risks of all-cause mortality, cancer-specific mortality and cancer recurrence in patients undergoing RC for bladder cancer.

Indexed as

CystectomyPerioperative PeriodAnimalsBlood TransfusionHumansTreatment OutcomeUrinary Bladder Neoplasms

Identifiers

PMID26080092
PMCPMC4469696
OpenAlexW637274380

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.