ArticlePloS one2015
The Relationship between Zinc Status and Inflammatory Marker Levels in Rural Korean Adults Aged 40 and Older.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Zinc Supplementation in Individuals with Prediabetes and type 2 Diabetes: a GRADE-Assessed Systematic Review and Dose-Response Meta-analysis.Biological trace element research · 2024Pooled it
- Thirteen weeks of supplementation of vitamin D and leucine-enriched whey protein nutritional supplement attenuates chronic low-grade inflammation in sarcopenic older adults: the PROVIDE study.Aging clinical and experimental research · 2019Trial
- Zinc, type 2 diabetes, diabetic kidney disease: focus on hypoxia.Frontiers in endocrinology · 2026Review
- Oxylipin dynamics in dairy cows during clinical ketosis and after treatment with niacin and flunixin meglumine.JDS communications · 2025Article
- Importance of Zinc Homeostasis for Normal Cardiac Rhythm.Current cardiology reviews · 2025Review
- Association of serum and hair antioxidant minerals with an oxidative stress marker in relation with characteristics of healthy adults: a cross-sectional study.Scientific reports · 2024Article
- The association between dietary intakes of zinc, vitamin C and COVID-19 severity and related symptoms: A cross-sectional study.Clinical nutrition ESPEN · 2023Article
- Zinc homeostasis and redox alterations in obesity.Frontiers in endocrinology · 2023Review
- Inflammatory-Metal Profile as a Hallmark for COVID-19 Severity During Pregnancy.Frontiers in cell and developmental biology · 2022Article
- Potential Nutrients from Natural and Synthetic Sources Targeting Inflammaging-A Review of Literature, Clinical Data and Patents.Nutrients · 2021Review
- Zinc and the Innovative Zinc-α2-Glycoprotein Adipokine Play an Important Role in Lipid Metabolism: A Critical Review.Nutrients · 2021Review
- Association between toenail zinc concentrations and incidence of asthma among American young adults: The CARDIA study.Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2021Article
- HIV-1 Virologic Rebound Due to Coadministration of Divalent Cations and Bictegravir.Infectious diseases and therapy · 2020Review
- Zinc at the crossroads of exercise and proteostasis.Redox biology · 2020Review
- Perinatal Whole Blood Zinc Status and Cytokines, Adipokines, and Other Immune Response Proteins.Nutrients · 2019Article
- Multiple micronutrient status and predictors of anemia in young children aged 12-23 months living in New Delhi, India.PloS one · 2019Article
- Design of a randomized controlled trial of zinc supplementation to improve markers of mortality and HIV disease progression in HIV-positive drinkers in St. Petersburg, Russia.HIV clinical trials · 2018Article
- Zinc status is associated with inflammation, oxidative stress, lipid, and glucose metabolism.The journal of physiological sciences : JPS · 2018Review
- Associations between serum bilirubin levels and essential trace elements status in an adult population.Oncotarget · 2017Article
- Copper to Zinc Ratio as Disease Biomarker in Neonates with Early-Onset Congenital Infections.Nutrients · 2017Observational
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSerum cytokines and C-reactive protein (CRP) are known as one of the major risk factors in atherosclerosis. The antioxidant and anti-inflammatory properties of zinc have been suggested, but few data are available on the relationship between zinc status and inflammatory markers in epidemiological studies.
objectiveThe present study aims to investigate the cross-sectional relationships of serum cytokines and CRP with dietary zinc intake and serum zinc levels in healthy men and women aged 40 and older in rural areas of South Korea. MATERIALS AND
methodsA group of 1,055 subjects (404 men, 651 women) was included in dietary zinc analysis while another group of 695 subjects (263 men, 432 women) was included in serum zinc analysis. Serum IL-6, TNF-α, and CRP were measured as inflammatory markers.
resultsThere was no significant inverse relationship between dietary zinc intake and inflammatory markers. We found a significant inverse relationship between serum zinc levels and all three inflammatory markers in women (P for trend = 0.0236 for IL-6; P for trend = 0.0017 for TNF-α; P for trend = 0.0301 for CRP) and between serum zinc levels and a single inflammatory marker (IL-6) in men (P for trend = 0.0191), although all R2 values by regression were less than 10%.
conclusionIn conclusion, serum zinc levels may be inversely related to inflammatory markers (IL-6, TNF-α, and CRP), particularly in women.
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