ArticlePloS one2015
Characterisation of Brachycephalic Obstructive Airway Syndrome in French Bulldogs Using Whole-Body Barometric Plethysmography.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed, 109 citations in OpenAlex.
- Vertebral Vascular Canal Dysplasia in Three Brachycephalic Breeds and Its Relationship With BOAS Grade.Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association · 2026Article
- Veterinarians' attitudes towards the treatment and surgical management of brachycephalic dogs - a survey among small animal veterinarians in Austria.BMC veterinary research · 2026Article
- Association of brachycephaly, sleep-disordered breathing, and inflammatory response in dogs.Journal of veterinary internal medicine · 2026Review
- Heart rate variability in dogs with brachycephalic obstructive airway syndrome evaluated during wakefulness and sleep.Journal of veterinary internal medicine · 2026Article
- Short-term changes in clinical status, cardiovascular function and heart rate variability after staphylectomy and alarplasty in French Bulldogs with brachycephalic obstructive airway syndrome.BMC veterinary research · 2026Article
- Pterygoid bone malformation and its limitations on the effectiveness of brachycephalic airway corrective surgery in brachycephalic dogs.The Journal of small animal practice · 2026Article
- Comprehensive Analysis of the Influence of Soft Palate Inflammation in Brachycephalic Dogs with BOAS III.Animals : an open access journal from MDPI · 2026Article
- Comparison of short- and long-term objective respiratory outcomes after surgery for brachycephalic obstructive airway syndrome.Veterinary surgery : VS · 2026Article
- Barometric whole-body plethysmography investigating breed-specific variations in dogs.Frontiers in veterinary science · 2026Article
- Timing-controlled concept for extubation in brachycephalic dogs: α2-bridged on-demand extubation.Frontiers in veterinary science · 2026Review
- A solution right under our nose? Crossbreeding extreme brachycephalic dogs results in better health outcomes while preserving behavioural profiles and dog-owner relationship quality.Animal welfare (South Mimms, England) · 2026Article
- Quantitative genetic analysis of respiratory function and related traits in Bulldogs, French Bulldogs and Pugs.PloS one · 2026Article
- Article
- Use of ultrasound to estimate tracheal diameter in unclipped brachycephalic dogs: A pilot study.Veterinary record open · 2025Article
- Lessons from changing soft tissue surgical referral trends for cats and dogs in a UK veterinary university teaching hospital between 2008 and 2018.Companion animal health and genetics · 2025Article
- Response to Two Standardized Exercise Tests in Dogs with Different Cephalic Biotypes.Veterinary sciences · 2025Article
- Beauty versus the beast: The UK public prefers less-extreme body shapes in brachycephalic dog breeds.The Veterinary record · 2025Article
- Complication rate and outcomes of laryngeal cuneiformectomy in dogs with advanced laryngeal collapse.Veterinary surgery : VS · 2025Article
- Comparison of remote and in-person respiratory function grading of brachycephalic dogs.Veterinary surgery : VS · 2025Article
- Perception of dog health and attitudes towards BOAS grading among Danish owners of French bulldog.Frontiers in veterinary science · 2025Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brachycephalic obstructive airway syndrome (BOAS) is an important health and welfare problem in several popular dog breeds. Whole-body barometric plethysmography (WBBP) is a non-invasive method that allows safe and repeated quantitative measurements of respiratory cycles on unsedated dogs. Here respiratory flow traces in French bulldogs from the pet population were characterised using WBBP, and a computational application was developed to recognise affected animals. Eighty-nine French bulldogs and twenty non-brachycephalic controls underwent WBBP testing. A respiratory functional grading system was used on each dog based on respiratory signs (i.e. respiratory noise, effort, etc.) before and after exercise. For development of an objective BOAS classifier, functional Grades 0 and I were considered to have insignificant clinical signs (termed here BOAS-) and Grades II and III to have significant signs (termed here BOAS+). A comparison between owner-perception of BOAS and functional grading revealed that 60 % of owners failed to recognise BOAS in dogs that graded BOAS+ in this study.WBBP flow traces were found to be significantly different between non-brachycephalic controls and Grade 0 French bulldogs; BOAS- and BOAS+ French bulldogs. A classifier was developed using quadratic discriminant analysis of the respiratory parameters to distinguish BOAS- and BOAS + French bulldogs, and a BOAS Index was calculated for each dog. A cut-off value of the BOAS Index was selected based on a receiver operating characteristic (ROC) curve. Sensitivity, specificity, positive predictive value, and negative predictive value of the classifier on the training group (n=69) were 0.97, 0.93, 0.95, and 0.97, respectively. The classifier was validated using a test group of French bulldogs (n=20) with an accuracy of 0.95. WBBP offers objective screening for the diagnosis of BOAS in French Bulldogs. The technique may be applied to other brachycephalic breeds affected by BOAS, and possibly to other respiratory disease in dogs.
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