Evidence map›Paper›PMID 26079646›Full record

ArticleExperimental neurology2015

Relative contributions of severe dopaminergic neuron ablation and dopamine depletion to cognitive impairment.

R Garrett Morgan, Jeffrey T Gibbs, Erica J Melief, Nadia O Postupna, Emily E Sherfield, Angela Wilson, C Dirk Keene, Thomas J Montine, Richard D Palmiter, Martin Darvas

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. The role of Foxo3a in neuron-mediated cognitive impairment.Frontiers in molecular neuroscience · 2024
    Review
  6. Review
  7. Article
  8. Failure of Diphtheria Toxin Model to Induce Parkinson-Like Behavior in Mice.International journal of molecular sciences · 2021
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

R Garrett MorganDepartment of Pathology, University of Washington School of Medicine, University of Washington, Box 357470, Seattle, WA 98195, USA.
Jeffrey T GibbsDepartment of Pathology, University of Washington School of Medicine, University of Washington, Box 357470, Seattle, WA 98195, USA.
Erica J MeliefDepartment of Pathology, University of Washington School of Medicine, University of Washington, Box 357470, Seattle, WA 98195, USA.
Nadia O PostupnaDepartment of Pathology, University of Washington School of Medicine, University of Washington, Box 357470, Seattle, WA 98195, USA.
Emily E SherfieldDepartment of Pathology, University of Washington School of Medicine, University of Washington, Box 357470, Seattle, WA 98195, USA.
Angela WilsonDepartment of Pathology, University of Washington School of Medicine, University of Washington, Box 357470, Seattle, WA 98195, USA.
C Dirk KeeneDepartment of Pathology, University of Washington School of Medicine, University of Washington, Box 357470, Seattle, WA 98195, USA.
Thomas J MontineDepartment of Pathology, University of Washington School of Medicine, University of Washington, Box 357470, Seattle, WA 98195, USA.
Richard D PalmiterDepartment of Biochemistry, University of Washington School of Medicine, University of Washington, Box 357350, Seattle, WA 98195, USA; Howard Hughes Medical Institute, University of Washington School of Medicine, University of Washington, Box 357350, Seattle, WA 98195, USA.
Martin DarvasDepartment of Pathology, University of Washington School of Medicine, University of Washington, Box 357470, Seattle, WA 98195, USA. Electronic address: mdarvas@uw.edu.
University of Washington · US

Funding

Udall Center Director's meeting poster awardP50NS062684 · NINDS · UNIVERSITY OF WASHINGTON · PI MONTINE, THOMAS J · 2009 to 2020
$18.3M
Environmetal Pathology/Toxicology Training ProgramT32ES007032 · NIEHS · UNIVERSITY OF WASHINGTON · PI FAUSTMAN, ELAINE M, ROSENFELD, MICHAEL E · 1985 to 2023
$10.7M
NEUROBEHAVIOR, NEUROENDOCRINOLOGY, AND GENETICS OF ADT32AG000258 · NIA · UNIVERSITY OF WASHINGTON · PI MONTINE, THOMAS J · 1999 to 2013
$4.7M
NIA NIH HHS T32 AG000258NIA NIH HHS T32-AG000258-15NIEHS NIH HHS T32 ES007032NIEHS NIH HHS T32-ES007032-37NINDS NIH HHS P50 NS062684NINDS NIH HHS P50-NS062684
6 · The paper itself

Abstract

Parkinson's disease (PD) is characterized by the loss of dopaminergic neurons and produces a movement disorder and cognitive impairment that becomes more extensive with the duration of the disease. To what extent cognitive impairment in advanced PD can be attributed to severe loss of dopamine (DA) signaling is not well understood. Furthermore, it is unclear if the loss of DA neurons contributes to the cognitive impairment caused by the reduction in DA signaling. We generated genetic mouse models with equally severe chronic loss of DA achieved by either extensive ablation of DA neurons or inactivation of DA synthesis from preserved neurons and compared their motor and cognitive performance. Motor behaviors were equally blunted in both models, but we observed that DA neuron ablation caused more severe cognitive deficits than DA depletion. Both models had marked deficits in cue-discrimination learning. Yet, deficits in cue-discrimination learning were more severe in mice with DA neuron ablation and only mice with DA neuron ablation had drastically impaired performance in spatial learning, spatial memory and object memory tests. These results indicate that while a severe reduction in DA signaling results in motor and cognitive impairments, the loss of DA neurons promotes more extensive cognitive deficits and suggest that a loss of additional factors that depend on DA neurons may participate in the progressive cognitive decline found in patients with PD.

Indexed as

AnimalsAnxietyBenzazepinesBenzothiazolesBrainCognition DisordersDiphtheria ToxinDiscrimination LearningDisease Models, AnimalDopamineDopamine AgonistsDopamine Plasma Membrane Transport ProteinsDopaminergic NeuronsGene Expression RegulationMemoryMiceBenzazepinesBenzothiazolesDiphtheria ToxinDopamineDopamine AgonistsDopamine Plasma Membrane Transport ProteinsPramipexoleSK&F 81297Tyrosine 3-MonooxygenaseAnimal modelDementiaDopamine lossNeurodegenerationParkinson's disease

Identifiers

PMID26079646
PMCPMC4586402
OpenAlexW562077006

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.