ArticleThe Journal of investigative dermatology2015
Ultrasonic Stimulation of Mouse Skin Reverses the Healing Delays in Diabetes and Aging by Activation of Rac1.
Article in The Journal of investigative dermatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04633642 (Cellular Proliferation, Dermal Repair, and Microbiological Effectiveness of Ultrasound Assisted Wound Debridement), which is not on this map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Cellular Proliferation, Dermal Repair, and Microbiological Effectiveness of Ultrasound Assisted Wound Debridement (UAW) Versus Standard Wound Treatment in Complicated Diabetic Foot Ulcers (DFU): A Randomized Controlled Trial
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- From mechanics to mobilization: a biomechanically-informed rehabilitation framework for cesarean-related scars.BMC women's health · 2026Pooled it
- Efficacy of Biophysical Energies on Healing of Diabetic Skin Wounds in Cell Studies and Animal Experimental Models: A Systematic Review.International journal of molecular sciences · 2019Pooled it
- Low-intensity pulsed ultrasound in acute multiple rib fracture-a prospective analysis, randomized controlled trial and pilot study.Journal of thoracic disease · 2025Article
- Human Parathyroid Hormone (1-34) accelerates skin wound healing through inducing cell migration via up-regulating the expression of Rac1.Cell division · 2024Article
- Effect of low frequency ultrasound waves on the morphology and viability of cultured human gingival fibroblasts.Journal of Taibah University Medical Sciences · 2023Article
- Ultrasound-triggered piezocatalytic composite hydrogels for promoting bacterial-infected wound healing.Bioactive materials · 2023Article
- Review
- Instructional review of key factors to achieve successful outcomes when using low-intensity pulsed ultrasound in fracture repair.EFORT open reviews · 2022Review
- Low-intensity pulsed ultrasound inhibits fibroblast-like synoviocyte proliferation and reduces synovial fibrosis by regulating Wnt/β-catenin signaling.Journal of orthopaedic translation · 2021Article
- Time- and Dose-Dependent Effects of Pulsed Ultrasound on Dermal Repair in Diabetic Mice.Ultrasound in medicine & biology · 2021Article
- Non pharmacological high-intensity ultrasound treatment of human dermal fibroblasts to accelerate wound healing.Scientific reports · 2021Article
- Application of low-intensity pulsed therapeutic ultrasound on mesenchymal precursors does not affect their cell properties.PloS one · 2021Article
- Cellular Proliferation, Dermal Repair, and Microbiological Effectiveness of Ultrasound-Assisted Wound Debridement (UAW) Versus Standard Wound Treatment in Complicated Diabetic Foot Ulcers (DFU): An Open-Label Randomized Controlled Trial.Journal of clinical medicine · 2020Article
- Wound healing: cellular mechanisms and pathological outcomes.Open biology · 2020Review
- Caveolin as a Universal Target in Dermatology.International journal of molecular sciences · 2019Review
- Development and Characterisation of a Human Chronic Skin Wound Cell Line-Towards an Alternative for Animal Experimentation.International journal of molecular sciences · 2018Article
- Topical Application of Tat-Rac1 Promotes Cutaneous Wound Healing in Normal and Diabetic Mice.International journal of biological sciences · 2018Article
- Low-intensity pulsed ultrasound promotes cell motility through vinculin-controlled Rac1 GTPase activity.Journal of cell science · 2017Article
- Ultrasound therapy in iliopsoas hematoma.Northern clinics of Istanbul · 2017Article
- A mechanism for ultrasound/light-induced biostimulation.Annals of translational medicine · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Chronic skin-healing defects are one of the leading challenges to lifelong well-being, affecting 2-5% of populations. Chronic wound formation is linked to age and diabetes and frequently leads to major limb amputation. Here we identify a strategy to reverse fibroblast senescence and improve healing rates. In healthy skin, fibronectin activates Rac1 in fibroblasts, causing migration into the wound bed, and driving wound contraction. We discover that mechanical stimulation of the skin with ultrasound can overturn healing defects by activating a calcium/CamKinaseII/Tiam1/Rac1 pathway that substitutes for fibronectin-dependent signaling and promotes fibroblast migration. Treatment of diabetic and aged mice recruits fibroblasts to the wound bed and reduces healing times by 30%, restoring healing rates to those observed in young, healthy animals. Ultrasound treatment is equally effective in rescuing the healing defects of animals lacking fibronectin receptors, and can be blocked by pharmacological inhibition of the CamKinaseII pathway. Finally, we discover that the migration defects of fibroblasts from human venous leg ulcer patients can be reversed by ultrasound, demonstrating that the approach is applicable to human chronic samples. By demonstrating that this alternative Rac1 pathway can substitute for that normally operating in the skin, we identify future opportunities for management of chronic wounds.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.