Evidence map›Paper›PMID 26079469›Full record

Trial reportContraception2015

Effects of initiating a contraceptive implant on subsequent condom use: A randomized controlled trial.

Carole Rattray, Jeffrey Wiener, Jennifer Legardy-Williams, Elizabeth Costenbader, Karen Pazol, Natalie Medley-Singh, Margaret C Snead, Markus J Steiner, Denise J Jamieson, Lee Warner and 3 more

Open access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Contraception, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
3.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Progestin-only contraceptives: effects on weight.The Cochrane database of systematic reviews · 2016
    Pooled it
  3. Trial
  4. Trial
  5. Trial
  6. Trial
  7. Article
  8. Article
  9. PrEP Use Among Female Sex Workers: No Evidence for Risk Compensation.Journal of acquired immune deficiency syndromes (1999) · 2019
    Observational
  10. Observational
  11. Article
  12. Dual method use among long-acting reversible contraceptive users.The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception · 2018
    Observational
  13. Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Carole RattrayUniversity Hospital of the West Indies, Kingston, Jamaica.
Jeffrey WienerCenters for Disease Control and Prevention, Atlanta, GA, USA.
Jennifer Legardy-WilliamsCenters for Disease Control and Prevention, Atlanta, GA, USA.
Elizabeth CostenbaderFamily Health International (FHI 360), Research Triangle Park, NC, USA.
Karen PazolCenters for Disease Control and Prevention, Atlanta, GA, USA.
Natalie Medley-SinghUniversity Hospital of the West Indies, Kingston, Jamaica.
Margaret C SneadUniversity Hospital of the West Indies, Kingston, Jamaica.
Markus J SteinerFamily Health International (FHI 360), Research Triangle Park, NC, USA.
Denise J JamiesonCenters for Disease Control and Prevention, Atlanta, GA, USA.
Lee WarnerCenters for Disease Control and Prevention, Atlanta, GA, USA.
Maria F GalloDivision of Epidemiology, The Ohio State University College of Public Health, Columbus, OH, USA.
Tina Hylton-KongEpidemiology Research and Training Unit, Ministry of Health, Kingston, Jamaica.
Athena P KourtisCenters for Disease Control and Prevention, Atlanta, GA, USA. Electronic address: apk3@cdc.gov.
Centers for Disease Control and Prevention · USUniversity Hospital of the West Indies · JMTriangle · USMinistry of Health · JMThe Ohio State University · US

Funding

Intramural CDC HHS CC999999
6 · The paper itself

Abstract

objectiveTo evaluate whether initiation of a contraceptive implant, a method of long-acting reversible contraception, reduces condom use, as measured by a biomarker of recent semen exposure [prostate-specific antigen (PSA)]. STUDY

designWe conducted a randomized controlled clinical trial in which 414 Jamaican women at high risk for sexually transmitted infections (STIs) attending family planning clinics received the contraceptive implant at baseline ("immediate" insertion arm, N=208) or at the end ("delayed" insertion arm, N=206) of a 3-month study period. Participants were tested for PSA at baseline and two follow-up study visits and were asked about their sexual activity and condom use.

resultsAt baseline, 24.9% of women tested positive for PSA. At both follow-up visits, the prevalence of PSA detection did not significantly differ between the immediate versus delayed insertion arm [1-month: 26.1% vs. 20.2%, prevalence ratio (PR)=1.3, 95% confidence interval (CI)=0.9-1.9; 3-month: 25.6% vs. 23.1%, PR= 1.1, 95% CI=0.8-1.6]. The change in PSA positivity over the three study visits was not significantly larger in the immediate arm compared to the delayed arm (1-sided p-value of .15).

conclusionsContraceptive implants can be successfully introduced into a population at high risk of unintended pregnancy and STIs without a biologically detectable difference in unprotected sex in the short term. This information strengthens the evidence to support promotion of implants in such populations and can help refine counseling for promoting and maintaining use of condoms among women who choose to use implants. IMPLICATIONS: Sex unprotected by a condom was not higher over 3 months in women receiving a contraceptive implant, compared with those not receiving the implant.

Indexed as

AdultAmbulatory Care FacilitiesBiomarkersCondomsContraceptionContraception BehaviorContraceptive Agents, FemaleDrug ImplantsFemaleFollow-Up StudiesHumansJamaicaMalePregnancyPregnancy, UnplannedProstate-Specific AntigenBiomarkersContraceptive Agents, FemaleDrug ImplantsProstate-Specific AntigenCondom useContraceptive implantLARCPSARandomized controlled trial

Identifiers

PMID26079469
PMCPMC11268953
OpenAlexW595332496

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.