ArticlePediatric pulmonology2015
Does the FEF25-75 or the FEF75 have any value in assessing lung disease in children with cystic fibrosis or asthma?
Article in Pediatric pulmonology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03839992 (The Measurement and Analysis of Maximal Expiratory Flow Volume Loops at Low Lung Volumes in Children With Cystic Fibrosis and Normal Routine Lung Function.), which is not on this map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Measurement and Analysis of Maximal Expiratory Flow Volume Loops at Low Lung Volumes in Children With Cystic Fibrosis and Normal Routine Lung Function.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- ARTP statement on pulmonary function testing 2020.BMJ open respiratory research · 2020Guideline
- Longitudinal changes in lung function in very prematurely born young people receiving high-frequency oscillation or conventional ventilation from birth.Pediatric pulmonology · 2022Trial
- Real-Life in Cystic Fibrosis Pediatric Patients Treated With Kaftrio: A Descriptive Observational Study.Clinical pediatrics · 2025Observational
- Article
- Article
- Isolated abnormal FEF75% detects unsuspected bronchiolar obstruction in CF children.Pediatric research · 2023Article
- The role of small airway function parameters in preschool asthmatic children.BMC pulmonary medicine · 2023Article
- Pulmonary Function Tests in Childhood Asthma: Which indices are Better for Assessment of Severity?Indian journal of pediatrics · 2023Article
- Bronchodilator Response in FEFRespiratory care · 2023Article
- Efficacy of hypertonic saline versus isotonic saline among children with cystic fibrosis: A systematic review and meta-analysis.Canadian journal of respiratory therapy : CJRT = Revue canadienne de la therapie respiratoire : RCTR · 2023Review
- Associations and dose-response relationships between different kinds of urine polycyclic aromatic hydrocarbons metabolites and adult lung functions.Environmental science and pollution research international · 2022Article
- Childhood lung function following perinatal HIV infection and early antiretroviral therapy initiation: a cross-sectional study.ERJ open research · 2022Article
- Normal Routine Spirometry Can Mask COPD/Emphysema in Symptomatic Smokers.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2021Article
- Early detection of lung function decrements in children and adolescents with cystic fibrosis using new reference values.Wiener klinische Wochenschrift · 2017Article
- The Use of Home Spirometry in Pediatric Cystic Fibrosis Patients: Results of a Feasibility Study.Global pediatric health · 2017Article
- Pattern of Lung Function Is Not Associated with Prior or Future Morbidity in Children with Sickle Cell Anemia.Annals of the American Thoracic Society · 2016Observational
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2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While the FEV1 had been recognized as an excellent indicator of disability, it is not very sensitive to early and mild disease. In cystic fibrosis (CF) small airway disease is believed to be one of the early hallmarks and indices such as the FEF25-75 and FEF75 have been proposed as sensitive markers of early disease. The site of early disease in asthma is not as well worked out. Recently a study of more than 20,000 spirometries found that neither of these indices added anything to the FEV1 /FVC but that study was not disease specific and contained both adults and children and the adults were the most numerous. To see if this would be true in children, 1,175 spirograms from children 6 to 18 years of age with CF or asthma whose FEV1 and FVC were above the lower limit of normal were taken from sequential studies. The data expressed in z scores was plotted with either the FEF25-75 or FEF75 plotted against FEV1 /FVC. In both diseases, but particularly in asthma, the FEV1 /FVC was more likely to be abnormal than either of the other two indices for suggesting that for children, early, or mild disease will be more apparent using the FEV1 /FVC than any other index.
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Registered trials
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