ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2015
Hyperlipidemia Promotes Anti-Donor Th17 Responses That Accelerate Allograft Rejection.
Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- The impact of dyslipidemia on skeletal health - from an immunoregulatory perspective.Frontiers in immunology · 2026Review
- Review
- Article
- The role of IL-6 in hyperlipidemia-induced accelerated rejection.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2022Article
- ACTH treatment promotes murine cardiac allograft acceptance.JCI insight · 2021Article
- Berberine Prolongs Mouse Heart Allograft Survival by Activating T Cell ApoptosisFrontiers in immunology · 2021Article
- Can Diet Induce Transplantation Tolerance?Journal of the American Society of Nephrology : JASN · 2020Article
- Predicting dyslipidemia after liver transplantation: A significant role of recipient metabolic inflammation profile.World journal of gastroenterology · 2020Observational
- Impact of the microbiota on solid organ transplant rejection.Current opinion in organ transplantation · 2019Review
- Hyperlipidemia and Allograft Rejection.Current transplantation reports · 2019Article
- Myeloid apolipoprotein E controls dendritic cell antigen presentation and T cell activation.Nature communications · 2018Article
- Hypercholesterolemia induces T cell expansion in humanized immune mice.The Journal of clinical investigation · 2018Article
- A New Concept of the Old Inhibitor NSC 74859 in Alleviating Cardiac Allograft Rejection and Extending Allograft Survival in Mice.Annals of transplantation · 2017Article
- Impact of environmental factors on alloimmunity and transplant fate.The Journal of clinical investigation · 2017Review
- Impact of hyperlipidemia on alloimmunity.Current opinion in organ transplantation · 2017Review
- Current status of alloimmunity.Current opinion in nephrology and hypertension · 2016Review
- High-Fat Diet-Induced Obesity Enhances Allograft Rejection.Transplantation · 2016Article
- Balancing Inflammation: The Link between Th17 and Regulatory T Cells.Mediators of inflammation · 2016Review
- Hyperlipidemia Alters Regulatory T Cell Function and Promotes Resistance to Tolerance Induction Through Costimulatory Molecule Blockade.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2015Article
Corrections and comments
- Commented on by
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Hyperlipidemia occurs in 95% of organ transplant recipients, however its effect on organ allograft rejection has not been investigated. We found that induction of hyperlipidemia in mice caused a significant acceleration of rejection of cardiac allografts. Accelerated rejection was associated with an aggressive T cell infiltrate that mediated significant tissue damage as well as increased serum levels of the proinflammatory cytokines IL-2, IL-6, and IL-17. Hyperlipidemic mice had an increased number of Th17 cells in their periphery and rejecting allografts from hyperlipidemic mice contained significant numbers of IL-17 producing T cells that were not detectable in transplants harvested from controls. Neutralization or genetic ablation of IL-17 prolonged survival of cardiac allografts transplanted into hyperlipidemic recipients, suggesting that IL-17 production promotes accelerated rejection. Analysis of alloreactive T cell frequencies directly ex vivo in naïve mice revealed that the frequency of donor reactive IL-17 producing cells in hyperlipidemic was increased prior to antigen exposure, suggesting that hyperlipidemia was sufficient to alter T cell alloreactivity and promote anti-donor Th17 responses on first exposure to antigen. Together, our data suggest that hyperlipidemia alters rejection by altering the types of T cell subsets that respond to donor antigen by promoting Th17 biased anti-donor reactivity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.