ArticleBritish journal of cancer2015
Preoperative neutrophil:lymphocyte and platelet:lymphocyte ratios predict endometrial cancer survival.
Article in British journal of cancer, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 5 of them syntheses that pooled it.
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Who cites it
71 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Pooled it
- Prognostic Significance of Pretreatment Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, or Monocyte-to-Lymphocyte Ratio in Endometrial Neoplasms: A Systematic Review and Meta-analysis.Frontiers in oncology · 2022Pooled it
- Prognostic values of pretreatment neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in endometrial cancer: a systematic review and meta-analysis.Archives of gynecology and obstetrics · 2020Pooled it
- The role of the systemic inflammatory response in predicting outcomes in patients with operable cancer: Systematic review and meta-analysis.Scientific reports · 2017Pooled it
- Prognostic role of lymphocyte to monocyte ratio for patients with cancer: evidence from a systematic review and meta-analysis.Oncotarget · 2016Pooled it
- Limited Incremental Value of Six Haemogram-Derived Inflammatory Indices for Detecting Endometrial Carcinoma and Intraepithelial Neoplasia in Abnormal Uterine Bleeding: A Case-Control Study.Diagnostics (Basel, Switzerland) · 2026Article
- Deciphering the predictors of endometrial nonbenign lesions in asymptomatic postmenopausal women via explainable machine learning.Menopause (New York, N.Y.) · 2026Article
- Prognostic value of C-reactive protein-albumin-lymphocyte index (CALLY) in patients with endometrial cancer under radical surgery.Frontiers in cell and developmental biology · 2026Article
- Identification of prognostic indicators for early recurrence of gastric cancer following laparoscopic gastrectomy.BMC surgery · 2025Article
- Clinical Utility of Pan-Immune Inflammation Value (PIV) in Predicting Prognosis of Endometrial Cancer.Journal of clinical medicine · 2025Article
- Neutrophil to Lymphocyte Ratio a Prognostic Tool in Endometrial Cancer Among Classical Prognostic Factors.Diagnostics (Basel, Switzerland) · 2025Article
- Article
- Prognostic significance of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and monocyte-to-lymphocyte ratio in uterine carcinosarcoma.International journal of clinical oncology · 2025Article
- Preoperative systemic inflammatory response index as a prognostic marker for distal cholangiocarcinoma after pancreatoduodenectomy.World journal of gastrointestinal surgery · 2024Article
- Article
- Two Hematological Markers Predicting the Efficacy and Prognosis of Neoadjuvant Chemotherapy Using Lobaplatin Against Triple-Negative Breast Cancer.The oncologist · 2024Article
- The predictive value of NLR, PLR and MLR in the differential diagnosis of benign uterine diseases and endometrial malignant tumors.Discover oncology · 2024Article
- Association of the systemic inflammation and anthropometric measurements with cancer risk: a prospective study in MJ cohort.Frontiers in oncology · 2024Article
- Prognostic Value of Fibrinogen to Prealbumin Ratio (FPR) in Resectable Gastric Cancer.Journal of inflammation research · 2024Article
- Systemic inflammatory indices for predicting prognosis of myelofibrosis.Scientific reports · 2023Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVariations in systemic inflammatory response biomarker levels have been associated with adverse clinical outcome in various malignancies. This study determined the prognostic significance of preoperative neutrophil:lymphocyte (NLR), platelet:lymphocyte (PLR) and monocyte:lymphocyte (MLR) ratios in endometrial cancer.
methodsClinicopathological and 5-year follow-up data were obtained for a retrospective series of surgically treated endometrial cancer patients (n=605). Prognostic significance was determined for overall (OS) and cancer-specific survival (CSS) using Cox proportional hazards models and Kaplan-Meier analysis. Receiver-operator characteristic and log-rank functions were used to optimise cut-offs. NLR, PLR and MLR associations with clinicopathological variables were determined using non-parametric tests.
resultsApplying cut-offs of ⩾2.4 (NLR), ⩾240 (PLR) and ⩾0.19 (MLR), NLR and PLR (but not MLR) had independent prognostic significance. Combining NLR and PLR scores stratified patients into low (NLR-low and PLR-low), intermediate (NLR-high or PLR-high) and high risk (NLR-high and PLR-high) groups: multivariable hazard ratio (HR) 2.51; P<0.001 (OS); HR 2.26; P<0.01 (CSS) for high vs low risk patients. Increased NLR and PLR were most strongly associated with advanced stage (P<0.001), whereas increased MLR was strongly associated with older age (P<0.001).
conclusionBoth NLR and PLR are independent prognostic indicators for endometrial cancer, which can be combined to provide additional patient stratification.
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