ArticleInfection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases2015
Wild waterfowl migration and domestic duck density shape the epidemiology of highly pathogenic H5N8 influenza in the Republic of Korea.
Article in Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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53 citing papers in PubMed.
- Production-Type-Specific Spatial and Space-Time Clustering of High-Pathogenicity Avian Influenza Outbreaks in Layer and Duck Farms in the Republic of Korea, 2020-2026.Animals : an open access journal from MDPI · 2026Article
- Avian Influenza at the Wild Bird-Poultry Interface: An Asia-Focused Review with Ecological Risk Scenarios for China.Animals : an open access journal from MDPI · 2026Review
- Optimizing wild bird fecal surveillance sites for HPAI through risk estimation using machine learning algorithms.One health (Amsterdam, Netherlands) · 2026Article
- Surveillance of avian influenza viruses in migratory wild birds in South Korea, 2019-2025.Journal of veterinary science · 2026Article
- Article
- Viral shedding and environmental dispersion of two clade 2.3.4.4b H5 high pathogenicity avian influenza viruses in experimentally infected mule ducks: implications for environmental sampling.Veterinary research · 2024Article
- Evolution and Spread of Highly Pathogenic Avian Influenza A(H5N1) Clade 2.3.4.4b Virus in Wild Birds, South Korea, 2022-2023.Emerging infectious diseases · 2024Article
- Diverse infectivity, transmissibility, and pathobiology of clade 2.3.4.4 H5Nx highly pathogenic avian influenza viruses in chickens.Emerging microbes & infections · 2023Article
- Article
- Bidirectional Movement of Emerging H5N8 Avian Influenza Viruses Between Europe and Asia via Migratory Birds Since Early 2020.Molecular biology and evolution · 2023Article
- Age is a determinant factor in the susceptibility of domestic ducks to H5 clade 2.3.2.1c and 2.3.4.4e high pathogenicity avian influenza viruses.Frontiers in veterinary science · 2023Article
- Risk Factors Contributing to Highly Pathogenic Avian Influenza H5N6 in China, 2014-2021: Based on a MaxEnt Model.Transboundary and emerging diseases · 2023Article
- Phylodynamic analysis of the highly pathogenic avian influenza H5N8 epidemic in France, 2016-2017.Transboundary and emerging diseases · 2022Article
- Article
- Wild Bird Densities and Landscape Variables Predict Spatial Patterns in HPAI Outbreak Risk across The Netherlands.Pathogens (Basel, Switzerland) · 2022Article
- Investigation of Avian Influenza H5N6 Virus-like Particles as a Broad-Spectrum Vaccine Candidate against H5Nx Viruses.Viruses · 2022Article
- Interpolation of Point Prevalence Rate of the Highly Pathogenic Avian Influenza Subtype H5N8 Second Phase Epidemic in South Korea.Veterinary sciences · 2022Article
- Spatial Variation in Risk for Highly Pathogenic Avian Influenza Subtype H5N6 Viral Infections in South Korea: Poultry Population-Based Case-Control Study.Veterinary sciences · 2022Article
- Risk Prediction of Three Different Subtypes of Highly Pathogenic Avian Influenza Outbreaks in Poultry Farms: Based on Spatial Characteristics of Infected Premises in South Korea.Frontiers in veterinary science · 2022Article
- Divergent Reassortment and Transmission Dynamics of Highly Pathogenic Avian Influenza A(H5N8) Virus in Birds of China During 2021.Frontiers in microbiology · 2022Article
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9 authors.
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Abstract
Highly pathogenic avian influenza (HPAI) viruses threaten human and animal health yet their emergence is poorly understood, partly because sampling of the HPAI Asian-origin H5N1 lineage immediately after its identification in 1996 was comparatively sparse. The discovery of a novel H5N8 virus in 2013 provides a new opportunity to investigate HPAI emergence in greater detail. Here we investigate the origin and transmission of H5N8 in the Republic of Korea, the second country to report the new strain. We reconstruct viral spread using phylogeographic methods and interpret the results in the context of ecological data on poultry density, overwintering wild bird numbers, and bird migration patterns. Our results indicate that wild waterfowl migration and domestic duck density were important to H5N8 epidemiology. Specifically, we infer that H5N8 entered the Republic of Korea via Jeonbuk province, then spread rapidly among western provinces where densities of overwintering waterfowl and domestic ducks are higher, yet rarely persisted in eastern regions. The common ancestor of H5N8 in the Republic of Korea was estimated to have arrived during the peak of inward migration of overwintering birds. Recent virus isolations likely represent re-introductions via bird migration from an as-yet unsampled reservoir. Based on the limited data from outside the Republic of Korea, our data suggest that H5N8 may have entered Europe at least twice, and Asia at least three times from this reservoir, most likely carried by wild migrating birds.
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