Evidence map›Paper›PMID 26079141›Full record

ArticleEmerging infectious diseases2015

Transdermal Diagnosis of Malaria Using Vapor Nanobubbles.

Ekaterina Lukianova-Hleb, Sarah Bezek, Reka Szigeti, Alexander Khodarev, Thomas Kelley, Andrew Hurrell, Michail Berba, Nirbhay Kumar, Umberto D'Alessandro, Dmitri Lapotko

Open access · diamondAbstract read
In one paragraph

Article in Emerging infectious diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
5.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Review
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  6. Diagnostic tools in childhood malaria.Parasites & vectors · 2018
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Ekaterina Lukianova-Hleb
Sarah Bezek
Reka Szigeti
Alexander Khodarev
Thomas Kelley
Andrew Hurrell
Michail Berba
Nirbhay Kumar
Umberto D'Alessandro
Dmitri Lapotko
Baylor College of Medicine · USPrecision Acoustics (United Kingdom) · GBRice University · USJohns Hopkins University · USLondon School of Hygiene & Tropical Medicine · GB

Funding

A DNA VACCINE TO PREVENT TRANSMISSION OF HUMAN MALARIAR01AI047089 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI KUMAR, NIRBHAY · 2000 to 2011
$3.6M
Malaria Vaccine Adjuvant Immunogenicity and SafetyR21AI101427 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI KUMAR, NIRBHAY · 2012 to 2013
$415k
Medical Research Council MC_UP_A900_1119NIAID NIH HHS AI101427NIAID NIH HHS AI47089NIAID NIH HHS R01 AI047089NIAID NIH HHS R21 AI101427
6 · The paper itself

Abstract

A fast, precise, noninvasive, high-throughput, and simple approach for detecting malaria in humans and mosquitoes is not possible with current techniques that depend on blood sampling, reagents, facilities, tedious procedures, and trained personnel. We designed a device for rapid (20-second) noninvasive diagnosis of Plasmodium falciparum infection in a malaria patient without drawing blood or using any reagent. This method uses transdermal optical excitation and acoustic detection of vapor nanobubbles around intraparasite hemozoin. The same device also identified individual malaria parasite-infected Anopheles mosquitoes in a few seconds and can be realized as a low-cost universal tool for clinical and field diagnoses.

Indexed as

AnimalsAnophelesFemaleHumansMalariaNanotechnologySkinSteamSteamAnopheles spp.bloodlessdiagnosishemozoinlasermalariananobubblenoninvasiveparasitesPlasmodium falciparumvector-borne infections

Identifiers

PMID26079141
PMCPMC4480396
OpenAlexW1989014064

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.