Evidence map›Paper›PMID 26079129›Full record

ArticleAmerican journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics2015

Significant association between rare IPO11-HTR1A variants and attention deficit hyperactivity disorder in Caucasians.

Lingjun Zuo, Laura Saba, Xiandong Lin, Yunlong Tan, Kesheng Wang, John H Krystal, Boris Tabakoff, Xingguang Luo

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PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Attention-deficit/hyperactive disorder updates.Frontiers in molecular neuroscience · 2022
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Lingjun ZuoDepartment of Psychiatry, Yale University School of Medicine, New Haven, Connecticut.
Laura SabaDepartment of Pharmacology, University of Colorado Denver School of Medicine, Aurora, Colorado.
Xiandong LinProvincial Key Laboratory of Translational Cancer Medicine, Fujian Provincial Cancer Hospital, Fuzhou, Fujian, China.
Yunlong TanBiological Psychiatry Research Center, Beijing Huilongguan Hospital, Beijing, China.
Kesheng WangDepartment of Biostatistics and Epidemiology, College of Public Health, East Tennessee State University, Johnson City, Tennessee.
John H KrystalDepartment of Psychiatry, Yale University School of Medicine, New Haven, Connecticut.
Boris TabakoffDepartment of Pharmacology, University of Colorado Denver School of Medicine, Aurora, Colorado.
Xingguang LuoDepartment of Psychiatry, Yale University School of Medicine, New Haven, Connecticut.
Yale University · USUniversity of Colorado Denver · USBeijing HuiLongGuan Hospital · CNEast Tennessee State University · USFujian Provincial Cancer Hospital · CN

Funding

Subject CollectionU10AA008401 · NIAAA · SUNY DOWNSTATE MEDICAL CENTER · PI JESSICA E SALVATORE · 1989 to 2026
$162.7M
JH/CIDR Genotyping for Genome-Wide Association StudiesU01HG004438 · NHGRI · JOHNS HOPKINS UNIVERSITY · PI VALLE, DAVID · 2007 to 2011
$24.2M
The Collaborative Genetic Study of Nicotine DependenceP01CA089392 · NCI · WASHINGTON UNIVERSITY · PI BIERUT, LAURA J. · 2001 to 2012
$17.3M
The Heritable Transcriptome and AlcoholismR24AA013162 · NIAAA · UNIVERSITY OF COLORADO DENVER · PI HOFFMAN, PAULA, SABA, LAURA MAREN · 2001 to 2021
$14.2M
Resource CoreP60AA011998 · NIAAA · WASHINGTON UNIVERSITY · PI MADDEN, PAMELA ANN · 2009 to 2013
$8.8M
MOLECULAR GENETICS OF SCHIZOPHRENIAR01MH059571 · NIMH · UNIVERSITY OF CHICAGO · PI GEJMAN, PABLO V. · 1999 to 2007
$8.0M
International Multi-Center ADHD Genetics ProjectR01MH062873 · NIMH · UPSTATE MEDICAL UNIVERSITY · PI FARAONE, STEPHEN V · 2002 to 2007
$7.2M
Genome Wide Association Coordinating CenterU01HG004446 · NHGRI · UNIVERSITY OF WASHINGTON · PI WEIR, BRUCE S. · 2007 to 2011
$6.6M
A Genome-Wide Association Study of SchizophreniaU01MH079469 · NIMH · NORTHSHORE UNIVERSITY HEALTHSYSTEM · PI GEJMAN, PABLO V. · 2007 to 2009
$4.4M
Statistical Methods in Genetic Studies of Substance UseR01DA016750 · NIDA · YALE UNIVERSITY · PI ZHANG, HEPING · 2004 to 2016
$3.3M
Genetics of Early Onset-StrokeR01NS045012 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI KITTNER, STEVEN J · 2003 to 2007
$3.3M
Molecular Epidemiology of Alcoholism 2- Big SibshipsR01AA013320 · NIAAA · WASHINGTON UNIVERSITY · PI HEATH, ANDREW C. · 2003 to 2007
$3.1M
Medical Research Council G0601030NCI NIH HHS P01 CA089392NHGRI NIH HHS HHSN268200782096CNHGRI NIH HHS U01 HG004422NHGRI NIH HHS U01HG004422NHGRI NIH HHS U01 HG004436NHGRI NIH HHS U01HG004436NHGRI NIH HHS U01 HG004438NHGRI NIH HHS U01HG004438NHGRI NIH HHS U01 HG004446NHGRI NIH HHS U01HG004446NIAAA NIH HHS P60 AA011998NIAAA NIH HHS P60AA011998NIAAA NIH HHS R01 AA013320NIAAA NIH HHS R01AA013320NIAAA NIH HHS R01 AA016015NIAAA NIH HHS R21 AA020319NIAAA NIH HHS R21 AA021380NIAAA NIH HHS R21 AA023237NIAAA NIH HHS R24 AA013162NIAAA NIH HHS R24 AA13162NIAAA NIH HHS U10 AA008401NIAAA NIH HHS U10AA008401NIDA NIH HHS K01 DA029643NIDA NIH HHS R01 DA013423NIDA NIH HHS R01DA013423NIDA NIH HHS R01 DA016750NIDA NIH HHS R01DA016750NIMH NIH HHS R01MH059160NIMH NIH HHS R01 MH059565NIMH NIH HHS R01 MH059566NIMH NIH HHS R01 MH059571NIMH NIH HHS R01 MH059586NIMH NIH HHS R01 MH059587NIMH NIH HHS R01 MH059588NIMH NIH HHS R01 MH060870NIMH NIH HHS R01 MH060879NIMH NIH HHS R01 MH061675NIMH NIH HHS R01 MH062873NIMH NIH HHS R01 MH067257NIMH NIH HHS R01 MH081800NIMH NIH HHS R01 MH081803NIMH NIH HHS R01MH081803NIMH NIH HHS R01MH59565NIMH NIH HHS R01MH59566NIMH NIH HHS R01MH59571NIMH NIH HHS R01MH59586NIMH NIH HHS R01MH59587NIMH NIH HHS R01MH59588NIMH NIH HHS R01MH60870NIMH NIH HHS R01MH60879NIMH NIH HHS R01MH61675NIMH NIH HHS R01MH62873NIMH NIH HHS R01MH67257NIMH NIH HHS R01MH81800NIMH NIH HHS U01 MH046276NIMH NIH HHS U01 MH046289NIMH NIH HHS U01 MH046318NIMH NIH HHS U01 MH079469NIMH NIH HHS U01 MH079470NIMH NIH HHS U01MH46282NIMH NIH HHS U01MH79469NIMH NIH HHS U01MH79470NINDS NIH HHS R01 NS045012NINDS NIH HHS R01NS45012Wellcome TrustWellcome Trust 075491/Z/04
6 · The paper itself

Abstract

We comprehensively examined the rare variants in the IPO11-HTR1A region to explore their roles in neuropsychiatric disorders. Five hundred seventy-three to 1,181 rare SNPs in subjects of European descent and 1,234-2,529 SNPs in subjects of African descent (0 < minor allele frequency (MAF) < 0.05) were analyzed in a total of 49,268 subjects in 21 independent cohorts with 11 different neuropsychiatric disorders. Associations between rare variant constellations and diseases and associations between individual rare variants and diseases were tested. RNA expression changes of this region were also explored. We identified a rare variant constellation across the entire IPO11-HTR1A region that was associated with attention deficit hyperactivity disorder (ADHD) in Caucasians (T5: P = 7.9 × 10(-31) ; Fp: P = 1.3 × 10(-32) ), but not with any other disorder examined; association signals mainly came from IPO11 (T5: P = 3.6 × 10(-10) ; Fp: P = 3.2 × 1 0(-10) ) and the intergenic region between IPO11 and HTR1A (T5: P = 4.1 × 10(-30) ; Fp: P = 5.4 × 10(-32) ). One association between ADHD and an intergenic rare variant, i.e., rs10042956, exhibited region- and cohort-wide significance (P = 5.2 × 10(-6) ) and survived correction for false discovery rate (q = 0.006). Cis-eQTL analysis showed that, 29 among the 41 SNPs within or around IPO11 had replicable significant regulatory effects on IPO11 exon expression (1.5 × 10(-17) ≤P < 0.002) in human brain or peripheral blood mononuclear cell tissues. We concluded that IPO11-HTR1A was a significant risk gene region for ADHD in Caucasians.

Indexed as

AdolescentAdultAttention Deficit Disorder with Hyperactivitybeta KaryopherinsBlack or African AmericanFemaleGene FrequencyGenetic Predisposition to DiseaseGenetic VariationHumansMaleMiddle AgedPolymorphism, Single NucleotideQuantitative Trait LociReceptor, Serotonin, 5-HT1ARisk Factorsbeta KaryopherinsHTR1A protein, humanIPO11 protein, humanReceptor, Serotonin, 5-HT1AADHDIPO11non-coding RNArare variant constellations

Identifiers

PMID26079129
PMCPMC4851708
OpenAlexW2126328740

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.