ArticleScientific reports2015
Cytokine profile in severe Gram-positive and Gram-negative abdominal sepsis.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 3 of them syntheses that pooled it.
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Who cites it
73 citing papers in PubMed, 3 syntheses or guidelines pooled it, 145 citations in OpenAlex.
- Prognostic differences in sepsis caused by gram-negative bacteria and gram-positive bacteria: a systematic review and meta-analysis.Critical care (London, England) · 2023Pooled it
- Clinical Characteristics and Diagnostic Challenges of COVID-19: An Update From the Global Perspective.Frontiers in public health · 2020Pooled it
- Diagnostic Accuracy of Procalcitonin Compared to C-Reactive Protein and Interleukin 6 in Recognizing Gram-Negative Bloodstream Infection: A Meta-Analytic Study.Disease markers · 2020Pooled it
- Noncanonical Surface Glycoconjugates fromJACS Au · 2026Article
- Risk factors for 28-day mortality and pathogen characteristics of septic shock in children: a 10-year retrospective cohort study.Frontiers in cellular and infection microbiology · 2026Article
- Characterising commensal and pathogenic staphylococcal interactions with neonatal and adult blood.Scientific reports · 2025Article
- Long-term outcomes of ICU-acquired infections with a focus on bloodstream infections: a single-center retrospective registry study.Infection · 2025Article
- Identification of protein biomarkers to differentiate between gram-negative and gram-positive infections in adults suspected of sepsis.BMC infectious diseases · 2025Article
- Sympathetic regulation of the host immune response to bacterial sepsis.Clinical science (London, England : 1979) · 2025Review
- Association Between F-SIRI and Adverse Prognosis in Patients With Chronic Heart Failure.Clinical cardiology · 2025Article
- Changes of Cytokines in Saliva of Pigs withVeterinary sciences · 2025Article
- Machine learning-based prognostic model for bloodstream infections in hematological malignancies using Th1/Th2 cytokines.BMC infectious diseases · 2025Article
- Cytokine-Based Insights into Bloodstream Infections and Bacterial Gram Typing in ICU COVID-19 Patients.Metabolites · 2025Article
- The real-world anti-inflammatory effect of SGLT2i in patients with chronic heart failure.Journal of medicine and life · 2025Article
- Article
- Lignanamides from the Roots ofACS omega · 2024Article
- Using the Traditional Ex Vivo Whole Blood Model to Discriminate Bacteria by Their Inducible Host Responses.Biomedicines · 2024Article
- Antibiotic-mediated dysbiosis leads to activation of inflammatory pathways.Frontiers in immunology · 2024Article
- Inflammation in Heart Failure-Future Perspectives.Journal of clinical medicine · 2023Review
- Non-Neuronal Acetylcholinesterase Activity Shows Limited Utility for Early Detection of Sepsis.Biomedicines · 2023Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sepsis is a principal cause of death in critical care units worldwide and consumes considerable healthcare resources. The aim of our study was to determine whether the early cytokine profile can discriminate between Gram-positive and Gram-negative bacteraemia (GPB and GNB, respectively) and to assess the prognostic value regarding outcome in critically ill patients with severe abdominal sepsis. The outcome measure was hospital mortality. Blood samples were obtained from 165 adult patients with confirmed severe abdominal sepsis. Levels of the proinflammatory mediators TNF-α, IL-8, IL-12 and IFN-γ and the anti-inflammatory mediators IL-1ra, IL-4, IL-10 and TGF-β1 were determined and correlated with the nature of the bacteria isolated from the blood culture and outcome. The cytokine profile in our study indicated that the TNF-α levels were 2-fold, IL-8 were 3.3-fold, IFN-γ were 13-fold, IL-1ra were 1.05-fold, IL-4 were 1.4-fold and IL-10 were 1.83-fold higher in the GNB group compared with the GPB group. The TNF-α levels were 4.7-fold, IL-8 were 4.6-fold, IL-1ra were 1.5-fold and IL-10 were 3.3-fold higher in the non-survivors compared with the survivors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.