Trial reportCurrent eye research2016
Longitudinal Changes in Lens Thickness in Myopic Children Enrolled in the Correction of Myopia Evaluation Trial (COMET).
Trial report in Current eye research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 3 syntheses or guidelines pooled it, 13 citations in OpenAlex.
- Interventions for myopia control in children: a living systematic review and network meta-analysis.The Cochrane database of systematic reviews · 2025Pooled it
- Interventions for myopia control in children: a living systematic review and network meta-analysis.The Cochrane database of systematic reviews · 2023Pooled it
- Interventions to slow progression of myopia in children.The Cochrane database of systematic reviews · 2020Pooled it
- Does the Lens Continue to Counteract Axial Elongation in Adults with High Myopia?Ophthalmology science · 2026Article
- Gender and Refractive Error Stratified Ocular Biometry Percentile Curves in Indian School Children.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026Article
- Correlation of the crystalline lens thickness and ocular parameters in young and middle-aged myopes grouped by axial length.BMC ophthalmology · 2025Article
- Longitudinal Changes in Lens Thickness and Lens Power Among Persistent Non-Myopic and Myopic Children.Investigative ophthalmology & visual science · 2022Article
- Elementary school comprehensive intervention and myopia development: the Wenzhou Epidemiology of Refraction Error Study.International journal of ophthalmology · 2022Article
- Prevalence and inconformity of refractive errors and ocular biometry of 3573 medical university freshman students for 4 consecutive years.International journal of ophthalmology · 2022Article
- Longitudinal association between myopia and parental myopia and outdoor time among students in Wenzhou: a 2.5-year longitudinal cohort study.BMC ophthalmology · 2021Article
- Axial Elongation in Myopic Children and its Association With Myopia Progression in the Correction of Myopia Evaluation Trial.Eye & contact lens · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
purposeTo describe longitudinal changes in lens thickness in myopic children in the Correction of Myopia Evaluation Trial (COMET) and to investigate the association between these changes and myopia progression.
methodsFour-hundred sixty-nine 6 to <12-year-old children with -1.25 to -4.50 D of myopia were enrolled in COMET, a clinical trial comparing single vision lenses (SVLs) versus progressive addition lenses (PALs) for slowing myopia. Children remained in their original lenses for 5 years and then could wear contact lenses, SVLs or PALs. Myopia by cycloplegic autorefraction (Nidek ARK 700A) and ocular components, including lens thickness, by A-scan ultrasound (Sonomed A2500) were measured annually over 11 years. Analyses of lens thickness were based on right eye data from 426 children with refractions fit with Gompertz functions. Longitudinal lens thickness measurements for each participant were fit with a third-degree polynomial function, and average polynomial functions were calculated for three groups of children previously identified based on Gompertz functions: 6-7 years at baseline (n = 40), ≥8 years with progressing myopia (n = 329), and ≥8 years with non-progressing myopia (n = 56). ANOVAs were used for comparing the lens curve-based parameters among the three groups. Associations between lens and Gompertz parameters were assessed using Pearson correlations.
resultsOverall, between 6 and 18 years the lenses thinned and then thickened, with the minimum value of 3.37 ± 0.15mm reached at 11.56 ± 2.04 years. The minimum lens thickness did not differ among the three myopia groups (p = 0.09), nor was it correlated with the amount of myopia at lens minimum or amount of final myopia (r's = -0.01 and -0.03, respectively, p's > 0.05).
conclusionAs a similar pattern of change in lens thickness with age was found in all children, whether their myopia progressed or not, these results suggest that the association of lens thinning and thickening with the course of myopia is coincidental rather than causal.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.