ArticleBioMed research international2015
In Vitro Antiproliferative Effect of the Acetone Extract of Rubus fairholmianus Gard. Root on Human Colorectal Cancer Cells.
Article in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Article
- Curcumin Modulates Oxidative Stress, Fibrosis, and Apoptosis in Drug-Resistant Cancer Cell Lines.Life (Basel, Switzerland) · 2022Article
- Comparative Investigation of Cellular Effects of Polyethylene Glycol (PEG) Derivatives.Polymers · 2022Article
- Article
- Increased Oxidative Stress Induced byOxidative medicine and cellular longevity · 2019Article
- Effects of methanolic extract from leaves of Rubus imperialis in DSS-induced colitis in mice.Inflammopharmacology · 2016Article
- In Vitro Antiproliferative and Antioxidant Effects of Extracts fromEvidence-based complementary and alternative medicine : eCAM · 2016Article
- Lead Phytochemicals for Anticancer Drug Development.Frontiers in plant science · 2016Review
- Anti-proliferative activity of Fumaria vaillantii extracts on different cancer cell lines.Research in pharmaceutical sciencesArticle
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Authors and funding
3 authors.
Funding
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Abstract
Plants and plant derived products exert chemopreventive effects on various cancer cell lines by the induction of cell death mechanisms. The effects of root acetone extract of Rubus fairholmianus (RFRA) on the proliferation of human colorectal cancer (Caco-2) cells have been investigated in this study. The extract led to a dose dependent decrease in both viability and proliferation and increased cytotoxicity using trypan blue exclusion, adenosine 5'-triphosphate (ATP), and lactate dehydrogenase (LDH) assay. The morphological features of the treated cells were supportive for the antiproliferative activity. The Annexin V/propidium iodide staining indicated that R. fairholmianus induced toxic effects in Caco-2 cells and the percentages of the early and late apoptotic population significantly increased when compared with control cells. Also we studied the apoptosis inducing ability of the extract by analysing caspase 3/7 activity and the induction of cell death via the effector caspases was confirmed; the activity increased in treated cells compared with control. Thus the present findings highlight that the R. fairholmianus root acetone extract exhibits antiproliferative activity on Caco-2 cells by the induction of apoptosis via caspase dependent pathway.
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