Evidence map›Paper›PMID 26078818›Full record

ReviewOxidative medicine and cellular longevity2015

Interaction of Hydrogen Sulfide with Oxygen Sensing under Hypoxia.

Bo Wu, Huajian Teng, Li Zhang, Hong Li, Jing Li, Lina Wang, Hongzhu Li

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Oxidative medicine and cellular longevity, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Bo WuDepartment of Pathophysiology, Harbin Medical University, Harbin 150086, China.
Huajian TengJoint Research Center for Bone and Joint Disease, Model Animal Research Center, Nanjing University, Nanjing 210093, China.
Li ZhangDepartment of Pathophysiology, Harbin Medical University, Harbin 150086, China.
Hong LiDepartment of Pathophysiology, Harbin Medical University, Harbin 150086, China.
Jing LiDepartment of Geriatrics, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China.
Lina WangDepartment of Pathophysiology, Harbin Medical University, Harbin 150086, China.
Hongzhu LiDepartment of Pathophysiology, Harbin Medical University, Harbin 150086, China.
Harbin Medical University · CNModel Animal Research Center · CNSecond Affiliated Hospital of Harbin Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Based on the discovery of endogenous H2S production, many in depth studies show this gasotransmitter with a variety of physiological and pathological functions. Three enzymes, cystathionine β-synthase (CBS), cystathionine γ-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (MST), are involved in enzymatic production of H2S. Emerging evidence has elucidated an important protective role of H2S in hypoxic conditions in many mammalian systems. However, the mechanisms by which H2S senses and responses to hypoxia are largely elusive. Hypoxia-inducible factors (HIFs) function as key regulators of oxygen sensing, activating target genes expression under hypoxia. Recent studies have shown that exogenous H2S regulates HIF action in different patterns. The activation of carotid bodies is a sensitive and prompt response to hypoxia, rapidly enhancing general O2 supply. H2S has been identified as an excitatory mediator of hypoxic sensing in the carotid bodies. This paper presents a brief review of the roles of these two pathways which contribute to hypoxic sensing of H2S.

Indexed as

HypoxiaAnimalsCystathionine beta-SynthaseCystathionine gamma-LyaseHydrogen SulfideHypoxia-Inducible Factor 1, alpha SubunitOxygenSulfurtransferases3-mercaptopyruvate sulphurtransferaseCystathionine beta-SynthaseCystathionine gamma-LyaseHydrogen SulfideHypoxia-Inducible Factor 1, alpha SubunitOxygenSulfurtransferases

Identifiers

PMID26078818
PMCPMC4442289
OpenAlexW1485485311

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.