ReviewOxidative medicine and cellular longevity2015
Vitamin A and Retinoids as Mitochondrial Toxicants.
Review in Oxidative medicine and cellular longevity, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
49 citing papers in PubMed, 98 citations in OpenAlex.
- Association between plasma retinol levels and the risk of all-cause mortality in general hypertensive patients: A nested case-control study.Journal of clinical hypertension (Greenwich, Conn.) · 2020Trial
- DHRS13 suppresses differentiation and mitophagy in glioma via retinoic acid and mitochondrial reactive oxygen species.Nature communications · 2025Article
- Carotenoids for Antiaging: Nutraceutical, Pharmaceutical, and Cosmeceutical Applications.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Progress on mitochondria and hair follicle development in androgenetic alopecia: relationships and therapeutic perspectives.Stem cell research & therapy · 2025Review
- Genomic and transcriptomic insights into vitamin A-induced thermogenesis and gene reuse as a cold adaptation strategy in wild boars.Communications biology · 2025Article
- RBP7 knockdown inhibits proliferation of human hepatocellular carcinoma and activates the p38 MAPK pathway.Frontiers in oncology · 2025Article
- Associations between vitamins intake and risk of cancer in United States adults: 2003 to 2016 national health and nutrition examination survey.Frontiers in nutrition · 2025Article
- The Antioxidant Potential of Vitamins and Their Implication in Metabolic Abnormalities.Nutrients · 2024Review
- Structure-Activity Relationships and Therapeutic Applications of Retinoids in View of Potential Benefits from Drug Repurposing Process.Biomedicines · 2024Review
- Integrated meta-omics reveals the regulatory landscape involved in lipid metabolism between pig breeds.Microbiome · 2024Article
- Associations between serum retinol and all-cause mortality among adults with prediabetes and diabetes: A cohort study.PloS one · 2024Article
- In Silico and In Vitro Methods in the Characterization of Beta-Carotene as Pharmaceutical Material via Acetylcholine Esterase Inhibitory Actions.Molecules (Basel, Switzerland) · 2023Article
- Understanding health disparities affecting people of West Central African descent in the United States: An evolutionary perspective.Evolutionary applications · 2023Review
- Vitamin A preserves cardiac energetic gene expression in a murine model of diet-induced obesity.American journal of physiology. Heart and circulatory physiology · 2022Article
- Fat-soluble vitamins: updated review of their role and orchestration in human nutrition throughout life cycle with sex differences.Nutrition & metabolism · 2022Review
- All-Oncology letters · 2022Article
- Personalized Medicine in Mitochondrial Health and Disease: Molecular Basis of Therapeutic Approaches Based on Nutritional Supplements and Their Analogs.Molecules (Basel, Switzerland) · 2022Review
- Hepatic Disorders and COVID-19: From Pathophysiology to Treatment Strategy.Canadian journal of gastroenterology & hepatology · 2022Review
- Article
- Role and Mechanism of Vitamin A Metabolism in the Pathophysiology of Parkinson's Disease.Journal of Parkinson's disease · 2021Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vitamin A and its derivatives, the retinoids, are micronutrient necessary for the human diet in order to maintain several cellular functions from human development to adulthood and also through aging. Furthermore, vitamin A and retinoids are utilized pharmacologically in the treatment of some diseases, as, for instance, dermatological disturbances and some types of cancer. In spite of being an essential micronutrient with clinical application, vitamin A exerts several toxic effects regarding redox environment and mitochondrial function. Moreover, decreased life quality and increased mortality rates among vitamin A supplements users have been reported. However, the exact mechanism by which vitamin A elicits its deleterious effects is not clear yet. In this review, the role of mitochondrial dysfunction in the mechanism of vitamin A-induced toxicity is discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.