ReviewStem cells international2015
Organ In Vitro Culture: What Have We Learned about Early Kidney Development?
Review in Stem cells international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 41 citations in OpenAlex.
- Effect of Hypoxia on Branching Characteristics and Cell Subpopulations during Kidney Organ Culture.Bioengineering (Basel, Switzerland) · 2022Article
- Multidisciplinary approaches for elucidating genetics and molecular pathogenesis of urinary tract malformations.Kidney international · 2022Review
- Updated perspectives on vascular cell specification and pluripotent stem cell-derived vascular organoids for studying vasculopathies.Cardiovascular research · 2022Review
- Vascular deficiencies in renal organoids and ex vivo kidney organogenesis.Developmental biology · 2021Article
- Prenatal low-dose methyltestosterone, but not dihydrotestosterone, treatment induces penile formation in female mice and guinea pigs†.Biology of reproduction · 2020Article
- Nephron repair: powered by anaerobic energy metabolism.Annals of translational medicine · 2019Article
- Ex vivo live cell tracking in kidney organoids using light sheet fluorescence microscopy.PloS one · 2018Article
- Exosomes as secondary inductive signals involved in kidney organogenesis.Journal of extracellular vesicles · 2018Article
- Concepts for a therapeutic prolongation of nephrogenesis in preterm and low-birth-weight babies must correspond to structural-functional properties in the nephrogenic zone.Molecular and cellular pediatrics · 2017Review
- Xenopus: leaping forward in kidney organogenesis.Pediatric nephrology (Berlin, Germany) · 2017Review
- Novel fixedDevelopment (Cambridge, England) · 2017Article
- Organ Culture and Whole Mount Immunofluorescence Staining of Mouse Wolffian Ducts.Journal of visualized experiments : JoVE · 2017Article
- The contribution of branching morphogenesis to kidney development and disease.Nature reviews. Nephrology · 2016Review
- Wnt Signaling in Renal Cell Carcinoma.Cancers · 2016Review
- Amniotic Fluid Stem Cells within Chimeric Kidney Rudiments Differentiate to Functional Podocytes after Transplantation into Mature Rat Kidneys.Journal of the American Society of Nephrology : JASN · 2016Article
- Special Morphological Features at the Interface of the Renal Stem/Progenitor Cell Niche Force to Reinvestigate Transport of Morphogens During Nephron Induction.BioResearch open access · 2016Review
- Signaling during Kidney Development.Cells · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
When Clifford Grobstein set out to study the inductive interaction between tissues in the developing embryo, he developed a method that remained important for the study of renal development until now. From the late 1950s on, in vitro cultivation of the metanephric kidney became a standard method. It provided an artificial environment that served as an open platform to study organogenesis. This review provides an introduction to the technique of organ culture, describes how the Grobstein assay and its variants have been used to study aspects of mesenchymal induction, and describes the search for natural and chemical inducers of the metanephric mesenchyme. The review also focuses on renal development, starting with ectopic budding of the ureteric bud, ureteric bud branching, and the generation of the nephron and presents the search for stem cells and renal progenitor cells that contribute to specific structures and tissues during renal development. It also presents the current use of Grobstein assay and its modifications in regenerative medicine and tissue engineering today. Together, this review highlights the importance of ex vivo kidney studies as a way to acquire new knowledge, which in the future can and will be implemented for developmental biology and regenerative medicine applications.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.