Evidence map›Paper›PMID 26078750›Full record

ArticleDementia and geriatric cognitive disorders extra

Free Recall Episodic Memory Performance Predicts Dementia Ten Years prior to Clinical Diagnosis: Findings from the Betula Longitudinal Study.

Carl-Johan Boraxbekk, Anders Lundquist, Annelie Nordin, Lars Nyberg, Lars-Göran Nilsson, Rolf Adolfsson

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Article in Dementia and geriatric cognitive disorders extra. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.

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40citing papers in PubMed, 2 pooled it
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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  19. Bidirectional Within- and Between-Person Relations Between Physical Activity and Cognitive Function.The journals of gerontology. Series B, Psychological sciences and social sciences · 2022
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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Carl-Johan BoraxbekkCEDAR -Center for Demographic and Aging Research, Stockholm, Sweden.
Anders LundquistDepartment of Statistics, Department of Integrative Medical Biology, Stockholm, Sweden.
Annelie NordinDivision of Psychiatry, Department of Clinical Sciences, Umeå University, Umeå, Stockholm, Sweden.
Lars NybergDivision of Physiology, Department of Integrative Medical Biology, Stockholm, Sweden ; Division of Diagnostic Radiology, Department of Radiation Sciences, Stockholm, Sweden.
Lars-Göran NilssonAging Research Center, Karolinska Institutet, Stockholm, Sweden.
Rolf AdolfssonDivision of Psychiatry, Department of Clinical Sciences, Umeå University, Umeå, Stockholm, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimsEarly dementia diagnosis is a considerable challenge. The present study examined the predictive value of cognitive performance for a future clinical diagnosis of late-onset Alzheimer's disease or vascular dementia in a random population sample.

methodsCognitive performance was retrospectively compared between three groups of participants from the Betula longitudinal cohort. Group 1 developed dementia 11-22 years after baseline testing (n = 111) and group 2 after 1-10 years (n = 280); group 3 showed no deterioration towards dementia during the study period (n = 2,855). Multinomial logistic regression analysis was used to investigate the predictive value of tests reflecting episodic memory performance, semantic memory performance, visuospatial ability, and prospective memory performance.

resultsAge- and education-corrected performance on two free recall episodic memory tests significantly predicted dementia 10 years prior to clinical diagnosis. Free recall performance also predicted dementia 11-22 years prior to diagnosis when controlling for education, but not when age was added to the model.

conclusionThe present results support the suggestion that two free recall-based tests of episodic memory function may be useful for detecting individuals at risk of developing dementia 10 years prior to clinical diagnosis.

Indexed as

Cognitive markersDementiaEpisodic memoryPredictive validity

Identifiers

PMID26078750
PMCPMC4463780

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.