Evidence map›Paper›PMID 26078578›Full record

ArticleWorld journal of gastroenterology2015

Assessment of the correlation between serum prolidase and alpha-fetoprotein levels in patients with hepatocellular carcinoma.

Sevil Uygun Ilikhan, Muammer Bilici, Hatice Sahin, Ayşe Semra Demir Akca, Murat Can, Ibrahim Ilker Oz, Berrak Guven, M Cagatay Buyukuysal, Yucel Ustundag

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastroenterology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07147335 (The Role of Serum AKR1B10 in Early Warning of Hepatocellular Carcinoma in Cirrhosis Patients ------ Risk Early Warning and Follow-up Study), which is not on this map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07147335 recruitingnot on this mapstarted 2025, after this paper: background citation

The Role of Serum AKR1B10 in Early Warning of Hepatocellular Carcinoma in Cirrhosis Patients ------ Risk Early Warning and Follow-up Study

Typeobservational_patient_registrySponsorThe First Affiliated Hospital of University of South ChinaRan2025 to 2028Enrolled800ConditionsCirrhosis, Hepotacellular CarcinomaArmsserum AKR1B10 levels
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
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  5. Article
  6. Long Noncoding RNAs and Human Liver Disease.Annual review of pathology · 2022
    Review
  7. Serum prolidase, malondialdehyde and catalase levels for the evaluation of oxidative stress in patients with peripheral vertigo.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2021
    Article
  8. Article
  9. Article
  10. Review
  11. Diagnostic value of alpha-fetoprotein,The Journal of international medical research · 2020
    Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Review
  17. Review
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Sevil Uygun IlikhanSevil Uygun Ilikhan, Muammer Bilici, Hatice Sahin, Department of Internal medicine, Bülent Ecevit University Faculty of Medicine, Zonguldak 67100, Turkey.
Muammer BiliciSevil Uygun Ilikhan, Muammer Bilici, Hatice Sahin, Department of Internal medicine, Bülent Ecevit University Faculty of Medicine, Zonguldak 67100, Turkey.
Hatice SahinSevil Uygun Ilikhan, Muammer Bilici, Hatice Sahin, Department of Internal medicine, Bülent Ecevit University Faculty of Medicine, Zonguldak 67100, Turkey.
Ayşe Semra Demir AkcaSevil Uygun Ilikhan, Muammer Bilici, Hatice Sahin, Department of Internal medicine, Bülent Ecevit University Faculty of Medicine, Zonguldak 67100, Turkey.
Murat CanSevil Uygun Ilikhan, Muammer Bilici, Hatice Sahin, Department of Internal medicine, Bülent Ecevit University Faculty of Medicine, Zonguldak 67100, Turkey.
Ibrahim Ilker OzSevil Uygun Ilikhan, Muammer Bilici, Hatice Sahin, Department of Internal medicine, Bülent Ecevit University Faculty of Medicine, Zonguldak 67100, Turkey.
Berrak GuvenSevil Uygun Ilikhan, Muammer Bilici, Hatice Sahin, Department of Internal medicine, Bülent Ecevit University Faculty of Medicine, Zonguldak 67100, Turkey.
M Cagatay BuyukuysalSevil Uygun Ilikhan, Muammer Bilici, Hatice Sahin, Department of Internal medicine, Bülent Ecevit University Faculty of Medicine, Zonguldak 67100, Turkey.
Yucel UstundagSevil Uygun Ilikhan, Muammer Bilici, Hatice Sahin, Department of Internal medicine, Bülent Ecevit University Faculty of Medicine, Zonguldak 67100, Turkey.
Bülent Ecevit University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo determine the predictive value of increased prolidase activity that reflects increased collagen turnover in patients with hepatocellular carcinoma (HCC).

methodsSixty-eight patients with HCC (mean age of 69.1 ± 10.1), 31 cirrhosis patients (mean age of 59.3 ± 6.3) and 33 healthy volunteers (mean age of 51.4 ± 12.6) were enrolled in this study. Univariate and multivariate analysis were used to evaluate the association of serum α-fetoprotein (AFP) values with HCC clinicopathological features, such as tumor size, number and presence of vascular and macrovascular invasion. The patients with HCC were divided into groups according to tumor size, number and presence of vascular invasion (diameters; ≤ 3 cm, 3-5 cm and ≥ 5 cm, number; 1, 2 and ≥ 3, macrovascular invasion; yes/no). Barcelona-clinic liver cancer (BCLC) criteria were used to stage HCC patients. Serum samples for measurement of prolidase and alpha-fetoprotein levels were kept at -80 °C until use. Prolidase levels were measured spectrophotometrically and AFP concentrations were determined by a chemiluminescence immunometric commercial diagnostic assay.

resultsIn patients with HCC, prolidase and AFP values were evaluated according to tumor size, number, presence of macrovascular invasion and BCLC staging classification. Prolidase values were significantly higher in patients with HCC compared with controls (P < 0.001). Prolidase levels were significantly associated with tumor size and number (P < 0.001, P = 0.002, respectively). Prolidase levels also differed in patients in terms of BCLC staging classification (P < 0.001). Furthermore the prolidase levels in HCC patients showed a significant difference compared with patients with cirrhosis (P < 0.001). In HCC patients grouped according to tumor size, number and BCLC staging classification, AFP values differed separately (P = 0.032, P = 0.038, P = 0.015, respectively). In patients with HCC, there was a significant correlation (r = 0.616; P < 0.001) between prolidase and AFP values in terms of tumor size, number and BCLC staging classification, whereas the presence of macrovascular invasion did not show a positive association with serum prolidase and AFP levels.

conclusionConsidering the levels of both serum prolidase and AFP could contribute to the early diagnosing of hepatocellular carcinoma.

Indexed as

AdultAgedalpha-FetoproteinsArea Under CurveCarcinoma, HepatocellularCase-Control StudiesCollagenDipeptidasesEarly Detection of CancerFemaleHumansLiver NeoplasmsMaleMiddle AgedMultivariate AnalysisNeoplasm InvasivenessAFP protein, humanalpha-FetoproteinsCollagenDipeptidasesproline dipeptidaseAlpha-fetoproteinCirrhosisHepatocellular carcinomaMacrovascular invasionProlidase

Identifiers

PMID26078578
PMCPMC4462742
OpenAlexW863775208

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.