ArticleWorld journal of gastroenterology2015
Association of colorectal cancer susceptibility variants with esophageal cancer in a Chinese population.
Article in World journal of gastroenterology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
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- Investigating the association between rs6983267 polymorphism and susceptibility to gastrointestinal cancers in Iranian population.Molecular biology reports · 2021Article
- Genetic variants in GHR and PLCE1 genes are associated with susceptibility to esophageal cancer.Molecular genetics & genomic medicine · 2020Article
- Multiple variants in collagen genes are associated with the susceptibility to lumbar disc herniation in the Chinese population.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2020Article
- IL-1B rs2853550 polymorphism contributes to esophageal cancer susceptibility in Chinese Han population of Northwest China.Molecular medicine (Cambridge, Mass.) · 2020Article
- Variants ofOncoTargets and therapy · 2020Article
- Association of SNPs in the OBFC1 gene and laryngeal carcinoma in Chinese Han male population.International journal of clinical oncology · 2019Article
- Analysis of MIR155HG variants and colorectal cancer susceptibility in Han Chinese population.Molecular genetics & genomic medicine · 2019Article
- Genetic variants in the ITPR2 gene are associated with Kashin-Beck Disease in Tibetan.Molecular genetics & genomic medicine · 2019Article
- Association between polymorphisms of MIR17HG and risk of colorectal cancer in the Chinese Han population.Molecular genetics & genomic medicine · 2019Article
- Association analysis of CHRNA3 polymorphisms with schizophrenia in a Chinese Han population: A case-control study.Medicine · 2018Observational
- Association of SNPs in the TIMP-2 gene and large artery atherosclerotic stroke in southern Chinese Han population.Oncotarget · 2018Article
- Association between IL-1 gene polymorphisms and tuberculosis susceptibility in the Chinese Tibetan population.International journal of clinical and experimental pathology · 2018Article
- RNAi-mediatedBioscience reports · 2017Article
- The RS4939827 polymorphism in the SMAD7 GENE and its association with Mediterranean diet in colorectal carcinogenesis.BMC medical genetics · 2017Article
- Association of genetic polymorphisms with laryngeal carcinoma prognosis in a Chinese population.Oncotarget · 2017Article
- Gene polymorphisms are associated with clinical outcome in Chinese resected laryngeal carcinoma patients.Oncotarget · 2016Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the association between colorectal cancer (CRC) genetic susceptibility variants and esophageal cancer in a Chinese Han population.
methodsA case-control study was conducted including 360 esophageal cancer patients and 310 healthy controls. Thirty-one single-nucleotide polymorphisms (SNPs) associated with CRC risk from previous genome-wide association studies were analyzed. SNPs were genotyped using Sequenom Mass-ARRAY technology, and genotypic frequencies in controls were tested for departure from Hardy-Weinberg equilibrium using a Fisher's exact test. The allelic frequencies were compared between cases and controls using a χ(2) test. Associations between the SNPs and the risk of esophageal cancer were tested using various genetic models (codominant, dominant, recessive, overdominant, and additive). ORs and 95%CIs were calculated by unconditional logistic regression with adjustments for age and sex.
resultsThe minor alleles of rs1321311 and rs4444235 were associated with a 1.53-fold (95%CI: 1.15-2.06; P = 0.004) and 1.28-fold (95%CI: 1.03-1.60; P = 0.028) increased risk of esophageal cancer in the allelic model analysis, respectively. In the genetic model analysis, the C/C genotype of rs3802842 was associated with a reduced risk of esophageal cancer in the codominant model (OR = 0.52, 95%CI: 0.31-0.88; P = 0.033) and recessive model (OR = 0.55, 95%CI: 0.34-0.87; P = 0.010). The rs4939827 C/T-T/T genotype was associated with a 0.67-fold (95%CI: 0.46-0.98; P = 0.038) decreased esophageal cancer risk under the dominant model. In addition, rs6687758, rs1321311, and rs4444235 were associated with an increased risk. In particular, the T/T genotype of rs1321311 was associated with an 8.06-fold (95%CI: 1.96-33.07; P = 0.004) increased risk in the codominant model.
conclusionThese results provide evidence that known genetic variants associated with CRC risk confer risk for esophageal cancer, and may bring risk for other digestive system tumors.
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