Evidence map›Paper›PMID 26078481›Full record

ArticleJournal of the American Statistical Association2015

Bayesian Inference of Multiple Gaussian Graphical Models.

Christine B Peterson, Francesco C Stingo, Marina Vannucci

Abstract read
In one paragraph

Article in Journal of the American Statistical Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed.

  1. Article
  2. Article
  3. Integrative Analysis of Multimodal Omics Data.Annual review of statistics and its application · 2026
    Article
  4. Article
  5. Article
  6. Connectivity Regression.Biostatistics (Oxford, England) · 2025
    Article
  7. Article
  8. Article
  9. Jointly estimating individual and group networks from fMRI data.Network neuroscience (Cambridge, Mass.) · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Covariate-Assisted Bayesian Graph Learning for Heterogeneous Data.Journal of the American Statistical Association · 2024
    Article
  15. Article
  16. Structure learning for gene regulatory networks.PLoS computational biology · 2023
    Article
  17. Article
  18. Article
  19. NETWORK DIFFERENTIAL CONNECTIVITY ANALYSIS.The annals of applied statistics · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Christine B PetersonDepartment of Health Research and Policy, Stanford University.
Francesco C StingoDepartment of Biostatistics, The University of Texas MD Anderson Cancer Center.
Marina VannucciDepartment of Statistics, Rice University.

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
Research ServicesP01HL082798 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI GREENE, ANDREW S. · 2006 to 2015
$22.0M
TRAINING PROGRAM IN COMPUTATIONAL BIOLOGY AND MEDICINET15LM007093 · NLM · RICE UNIVERSITY · PI Lydia E. Kavraki · 1992 to 2026
$20.8M
Training Program in Biostatistics for Cancer ResearchT32CA096520 · NCI · RICE UNIVERSITY · PI KIMMEL, MAREK, YUAN, YING · 2003 to 2023
$4.5M
NCI NIH HHS P30 CA016672NCI NIH HHS T32 CA096520NHLBI NIH HHS P01 HL082798NLM NIH HHS T15 LM007093
6 · The paper itself

Abstract

In this paper, we propose a Bayesian approach to inference on multiple Gaussian graphical models. Specifically, we address the problem of inferring multiple undirected networks in situations where some of the networks may be unrelated, while others share common features. We link the estimation of the graph structures via a Markov random field (MRF) prior which encourages common edges. We learn which sample groups have a shared graph structure by placing a spike-and-slab prior on the parameters that measure network relatedness. This approach allows us to share information between sample groups, when appropriate, as well as to obtain a measure of relative network similarity across groups. Our modeling framework incorporates relevant prior knowledge through an edge-specific informative prior and can encourage similarity to an established network. Through simulations, we demonstrate the utility of our method in summarizing relative network similarity and compare its performance against related methods. We find improved accuracy of network estimation, particularly when the sample sizes within each subgroup are moderate. We also illustrate the application of our model to infer protein networks for various cancer subtypes and under different experimental conditions.

Indexed as

Bayesian inferenceGaussian graphical modelG-Wishart priorMarkov random fieldprotein network

Identifiers

PMID26078481
PMCPMC4465207

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.