ArticleInternational journal of epidemiology2015
Life-course body mass index trajectories and blood pressure in mid life in two British birth cohorts: stronger associations in the later-born generation.
Article in International journal of epidemiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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22 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Systematic Review and Regression Modeling of the Effects of Age, Body Size, and Exercise on Cardiovascular Parameters in Healthy Adults.Cardiovascular engineering and technology · 2022Pooled it
- The Importance of Sensitivity Analyses for the MR Steiger Approach.Genetic epidemiology · 2025Article
- Investigating change across time in prevalence or association: the challenges of cross-study comparative research and possible solutions.Discover social science and health · 2022Article
- Changes in the body mass index and blood pressure association across time: Evidence from multiple cross-sectional and cohort studies.Preventive medicine · 2021Article
- Predictive value of women's weight trajectories in determining familial cardiovascular disorders: a family-based longitudinal study.Scientific reports · 2021Article
- Prevalence and early-life determinants of mid-life multimorbidity: evidence from the 1970 British birth cohort.BMC public health · 2021Article
- Systolic Blood Pressure Mediates Body Mass Index and Non-alcoholic Fatty Liver Disease: A Population-Based Study.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2021Article
- Changes over time in latent patterns of childhood-to-adulthood BMI development in Great Britain: evidence from three cohorts born in 1946, 1958, and 1970.BMC medicine · 2021Article
- The Association between Blood Pressure Trajectories and Risk of Cardiovascular Diseases among Non-Hypertensive Chinese Population: A Population-Based Cohort Study.International journal of environmental research and public health · 2021Article
- Body mass index trajectories during mid to late life and risks of mortality and cardiovascular outcomes: Results from four prospective cohorts.EClinicalMedicine · 2021Article
- Body Mass Index Trajectories during 6-18 Years Old and the Risk of Hypertension in Young Adult: A Longitudinal Study in Chinese Population.International journal of hypertension · 2021Article
- Socioeconomic inequalities in blood pressure: co-ordinated analysis of 147,775 participants from repeated birth cohort and cross-sectional datasets, 1989 to 2016.BMC medicine · 2020Article
- Secular Trends of the Impact of Overweight and Obesity on Hypertension in Yi People: Yi Migrant Study, 1996-2015.International journal of hypertension · 2020Article
- Life-course trajectories of body mass index and subsequent cardiovascular risk among Chinese population.PloS one · 2019Article
- Body mass index trajectories in childhood is predictive of cardiovascular risk: results from the 23-year longitudinal Georgia Stress and Heart study.International journal of obesity (2005) · 2018Article
- Bayesian hierarchical piecewise regression models: a tool to detect trajectory divergence between groups in long-term observational studies.BMC medical research methodology · 2017Article
- Assessing the reporting of categorised quantitative variables in observational epidemiological studies.BMC health services research · 2017Observational
- Depression and alexithymia on weight perception in patients with metabolic syndrome and type 2 diabetes.Diabetology & metabolic syndrome · 2017Article
- Article
- Body mass trajectories, diabetes mellitus, and mortality in a large cohort of Austrian adults.Medicine · 2016Observational
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4 authors at 2 institutions in 1 country.
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Abstract
backgroundLittle is known about the impact of recent increases in obesity and more rapid gains in body mass index (BMI) on cardiovascular risk factors. We investigated life-course BMI trajectories associations with adult blood pressure (BP) across two generations.
methodsWe used the the 1946 and 1958 British birth cohorts. Joint multivariate response models were fitted to longitudinal BMI measures [7, 11, 16, 20, 26, 36, 43 and 50 y (years): 1946 cohort, n = 4787; 7, 11, 16, 23, 33 and 45 y: 1958 cohort, n = 16,820] and mid-adult BP. We adopted linear spline models with random coefficients to characterize childhood and adult BMI slopes.
resultsMean systolic BP (SBP) decreased from the earlier- to later-born cohort by 2.8 mmHg in females, not males; mean diastolic BP (DBP) decreased by 3.2-3.3 mmHg (both sexes). Adult BMI was higher in the later- than the earlier-born cohort by 1.3-1.8 kg/m(2), slopes of BMI trajectory were steeper from early adulthood and associations with adult BP were stronger. Associations between adult BMI and SBP were stronger in the later-born cohort. For males, childhood BMI slope was associated with SBP only in the later-born cohort; the association for adult BMI slope was stronger in the later-born cohort: correlation coefficient r = 0.28 [95% confidence interval (CI): 0.25,0.33] versus 0.13 (0.06,0.20). For females, childhood slope was associated with SBP in both cohorts; adult slope was associated with SBP only in the 1958 cohort [r = 0.34 (0.31,0.37)]. Patterns of child-to-adult BMI associations were similar in relation to DBP.
conclusionsBP did not increase between two generations born 12 y apart despite higher BMI levels. A stronger association between BMI trajectory and BP in the later-born cohort suggests that BMI-related effects may have been offset by improvements in other factors linked to BP, such as diet and smoking.
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