ArticleSocial cognitive and affective neuroscience2016
Significant grey matter changes in a region of the orbitofrontal cortex in healthy participants predicts emotional dysregulation.
Article in Social cognitive and affective neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 37 citations in OpenAlex.
- Chronic Pain and Cognitive Dysfunction: Clinical Implement, Mechanism, and Therapeutic Strategy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Review
- Specific frontostriatal structural alterations underlie emotional instability but not inattention in ADHD and healthy individuals.Journal of psychiatry & neuroscience : JPN · 2026Article
- Microstructural Brain Correlates of Inter-individual Differences in Respiratory Interoception.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Parsing brain-behavior heterogeneity in very preterm born children using integrated similarity networks.Translational psychiatry · 2023Article
- Dark triad personality traits are associated with decreased grey matter volumes in 'social brain' structures.Frontiers in psychology · 2023Article
- A Voxel-Based Morphometric Study of Gray Matter in Specific Phobia.Life (Basel, Switzerland) · 2022Article
- Mediating Role of Psychological Inflexibility as Transdiagnostic Factor in the Relationship Between Emotional Dysregulation and Sleep Problems With Symptoms of Emotional Disorders.Frontiers in psychology · 2022Article
- Divergent effects of irradiation on brain cortical morphology in patients with nasopharyngeal carcinoma: one-year follow-up study using structural magnetic resonance imaging.Quantitative imaging in medicine and surgery · 2021Article
- Distinct brain structure and behavior related to ADHD and conduct disorder traits.Molecular psychiatry · 2020Article
- Association of self-regulation with white matter correlates in boys with and without autism spectrum disorder.Scientific reports · 2020Article
- Emotional Instability Relates to Ventral Striatum Activity During Reward Anticipation in Females.Frontiers in behavioral neuroscience · 2020Article
- Gray Matter Volume Correlates of Sleepiness: A Voxel-Based Morphometry Study in Younger and Older Adults.Nature and science of sleep · 2020Article
- Research on Factors Affecting the Entrepreneurial Learning From Failure: An Interpretive Structure Model.Frontiers in psychology · 2019Article
- The resilient brain: psychological resilience mediates the effect of amplitude of low-frequency fluctuations in orbitofrontal cortex on subjective well-being in young healthy adults.Social cognitive and affective neuroscience · 2018Article
- The multifaceted abstract brain.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- Assessment of Patient Self-awareness and Related Neural Correlates in Frontotemporal Dementia and Corticobasal Syndrome.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2018Article
- Examining Brain Structures Associated With Emotional Intelligence and the Mediated Effect on Trait Creativity in Young Adults.Frontiers in psychology · 2018Article
- Top-Down Dysregulation-From ADHD to Emotional Instability.Frontiers in behavioral neuroscience · 2016Article
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The traditional concept of 'categorical' psychiatric disorders has been challenged as many of the symptoms display a continuous distribution in the general population. We suggest that this is the case for emotional dysregulation, a key component in several categorical psychiatric disorder constructs. We used voxel-based magnetic resonance imaging morphometry in healthy human subjects (n = 87) to study how self-reported subclinical symptoms associated with emotional dysregulation relate to brain regions assumed to be critical for emotion regulation. To measure a pure emotional dysregulation, we also corrected for subclinical symptoms of non-emotional attentional dysregulation. We show that such subclinical emotional symptoms correlate negatively with the grey matter volume of lateral orbitofrontal cortex bilaterally-a region assumed to be critical for emotion regulation and dysfunctional in psychiatric disorders involving emotional dysregulation. Importantly, this effect is mediated both by a decrease in volume associated with emotional dysregulation and an increase in volume due to non-emotional attentional dysregulation. Exploratory analysis suggests that other regions involved in emotional processing such as insula and ventral striatum also show a similar reduction in grey matter volume mirroring clinical disorders associated with emotional dysregulation. Our findings support the concept of continuous properties in psychiatric symptomatology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.