Evidence map›Paper›PMID 26078306›Full record

SynthesisBMJ open2015

Single-dose intra-articular bupivacaine plus morphine after knee arthroscopic surgery: a meta-analysis of randomised placebo-controlled studies.

Yi-lun Wang, Chao Zeng, Dong-xing Xie, Ye Yang, Jie Wei, Tuo Yang, Hui Li, Guang-hua Lei

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMJ open, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yi-lun WangDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
Chao ZengDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
Dong-xing XieDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
Ye YangDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
Jie WeiDepartment of Epidemiology and Health Statistics, School of Public Health, Central South University, Changsha, Hunan Province, China.
Tuo YangDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
Hui LiDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
Guang-hua LeiDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo evaluate the efficacy and safety of single-dose intra-articular bupivacaine plus morphine after knee arthroscopic surgery.

designMeta-analysis. DATA SOURCES AND STUDY ELIGIBILITY CRITERIA: A comprehensive literature search, using Medline (1966-2014), the Cochrane Central Register of Controlled Trials and Embase databases, was conducted to identify randomised placebo-controlled trials that used a combination of single-dose intra-articular bupivacaine and morphine for postoperative pain relief.

results12 articles were included in this meta-analysis. The mean visual analogue scale (VAS) scores of the bupivacaine plus morphine group were significantly lower than those of the placebo group (weighted mean difference (WMD) -1.75; 95% CI -2.16 to -1.33; p<0.001). The VAS scores at the last follow-up time point (last VAS scores) of the bupivacaine plus morphine group were also significantly lower than those of the placebo group (WMD -1.46; 95% CI -1.63 to -1.29; p<0.001). The number of patients requiring supplementary analgesia was also significantly reduced (RR 0.60; 95% CI 0.39 to 0.93; p=0.02), while there was no significant difference in the time to first analgesic request (WMD 3.46; 95% CI -1.81 to 8.72; p=0.20) or short-term side effects (RR 1.67; 95% CI 0.65 to 4.26; p=0.29).

conclusionsThe administration of single-dose intra-articular bupivacaine plus morphine after knee arthroscopic surgery is effective for pain relief, and its short-term side effects remain similar to saline placebo.

Indexed as

AnalgesiaAnalgesics, OpioidAnesthetics, LocalArthroscopyBupivacaineHumansKneeKnee JointMorphineMusculoskeletal PainPostoperative PainTreatment OutcomeAnalgesics, OpioidAnesthetics, LocalBupivacaineMorphineANAESTHETICSSTATISTICS & RESEARCH METHODS

Identifiers

PMID26078306
PMCPMC4480015

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.