Evidence map›Paper›PMID 26078115›Full record

Trial reportAIDS and behavior2016

Depression and Oral FTC/TDF Pre-exposure Prophylaxis (PrEP) Among Men and Transgender Women Who Have Sex With Men (MSM/TGW).

Patricia A Defechereux, Megha Mehrotra, Albert Y Liu, Vanessa M McMahan, David V Glidden, Kenneth H Mayer, Lorena Vargas, K Rivet Amico, Piotr Chodacki, Telmo Fernandez and 4 more

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in AIDS and behavior, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 48 citations in OpenAlex.

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  10. Early Sexual Initiation Is Associated with Suicide Attempts among Chinese Young People.International journal of environmental research and public health · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 5 countries.

Patricia A DefechereuxJ. David Gladstone Institutes, Grant Lab, GIVI, 5th Floor, 1650 Owens Street, San Francisco, 94158, CA, USA.
Megha MehrotraJ. David Gladstone Institutes, Grant Lab, GIVI, 5th Floor, 1650 Owens Street, San Francisco, 94158, CA, USA.
Albert Y LiuBridge HIV, San Francisco Department of Public Health, San Francisco, CA, USA.
Vanessa M McMahanJ. David Gladstone Institutes, Grant Lab, GIVI, 5th Floor, 1650 Owens Street, San Francisco, 94158, CA, USA.
David V GliddenUniversity of California, San Francisco, CA, USA.
Kenneth H MayerFenway Community Health, Boston, MA, USA.
Lorena VargasInvestigaciones Medicas en Salud, Lima, Peru.
K Rivet AmicoSchool of Public Health, University of Michigan, Ann Arbor, MI, USA.
Piotr ChodackiDesmond Tutu HIV Foundation, University of Cape Town, Cape Town, South Africa.
Telmo FernandezFundacion Ecuatoriana Equidad, Guayaquil, Ecuador.
Vivian I Avelino-SilvaUniversity of Sao Paulo Medical School, Sao Paulo, Brazil.
David BurnsNational Institutes of Health, Bethesda, MD, USA.
Robert M GrantJ. David Gladstone Institutes, Grant Lab, GIVI, 5th Floor, 1650 Owens Street, San Francisco, 94158, CA, USA. robert.grant@ucsf.edu.
iPrEx Study Team
Gladstone Institutes · USDesmond Tutu HIV Foundation · ZANational Institutes of Health · USEsSALUD · PEUniversidade de São Paulo · BRUniversity of California, San Francisco · USUniversity of Michigan · US

Funding

Chemoprophylaxis for HIV Prevention in Men SupplementU01AI064002 · NIAID · J. DAVID GLADSTONE INSTITUTES · PI GRANT, ROBERT M. · 2005 to 2011
$41.3M
Chemoprophylaxis and HIV Host InteractionsR01AI118575 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANT, ROBERT M. · 2015 to 2019
$2.9M
NIAID NIH HHS R01 AI118575NIAID NIH HHS U01 AI064002
6 · The paper itself

Abstract

We conducted a longitudinal and cross-sectional analysis of depressive symptomology in iPrEx, a randomized, placebo-controlled trial of daily, oral FTC/TDF HIV pre-exposure prophylaxis (PrEP) in men and transgender women who have sex with men. Depression-related adverse events (AEs) were the most frequently reported severe or life-threatening AEs and were not associated with being randomized to the FTC/TDF arm (152 vs. 144 respectively OR 0.66 95 % CI 0.35-1.25). Center for Epidemiologic Studies Depression scale (CES-D) and a four questions suicidal ideation scale scores did not differ by arm. Participants reporting forced sex at anal sexual debut had higher CES-D scores (coeff: 3.23; 95 % CI 1.24-5.23) and were more likely to have suicidal ideation (OR 2.2; 95 % CI 1.09-4.26). CES-D scores were higher among people reporting non-condom receptive anal intercourse (ncRAI) (OR 1.46; 95 % CI 1.09-1.94). We recommend continuing PrEP during periods of depression in conjunction with provision of mental health services.

Indexed as

Pre-Exposure ProphylaxisAdolescentAdultAnti-HIV AgentsCross-Sectional StudiesDepressionEmtricitabineFemaleHIV InfectionsHomosexuality, MaleHumansLongitudinal StudiesMaleMiddle AgedSexual BehaviorTenofovirAnti-HIV AgentsEmtricitabineTenofovirDepressionFTC/TDFHIV preventioniPrExMen who have sex with menPrEP

Identifiers

PMID26078115
PMCPMC4903104
OpenAlexW571061083

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.