ArticleThe Journal of allergy and clinical immunology2015
Association between vitamin D levels and allergy-related outcomes vary by race and other factors.
Article in The Journal of allergy and clinical immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02889081 (Maternal Key Nutritional Factors and Offspring's Atopic Dermatitis), which is not on this map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Maternal Key Nutritional Factors and Offspring's Atopic Dermatitis
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Early life vitamin D status and asthma and wheeze: a systematic review and meta-analysis.BMC pulmonary medicine · 2018Pooled it
- Neonatal vitamin D status and asthma risk after age 5 years: A Danish population-based cohort study.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026Article
- The Role of Prenatal Vitamin D Deficiency in Early Allergic Rhinitis in Neonates in Greece: Insights from a Cross-Sectional Study at the "Tzaneio" General Hospital.Clinics and practice · 2025Article
- Association of cord blood vitamin D and genetic polymorphisms with childhood food allergy in Shanghai, China: a prospective cohort.Frontiers in nutrition · 2025Article
- Vitamin D and allergic diseases.Frontiers in immunology · 2024Review
- Prenatal and child vitamin D levels and allergy and asthma in childhood.Pediatric research · 2023Article
- Prenatal Vitamin D Levels Influence Growth and Body Composition until 11 Years in Boys.Nutrients · 2023Article
- Maternal vitamin D in pregnancy and infant's gut microbiota: a systematic review.Frontiers in pediatrics · 2023Review
- Transcriptional responses of liver and spleen inFrontiers in immunology · 2023Article
- Pre- and Postnatal Vitamin D Status and Allergy Outcomes in Early Childhood.Biomedicines · 2022Review
- Prenatal vitamin D levels and child wheeze and asthma.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2021Article
- Effect of maternal sleep, physical activity and screen time during pregnancy on the risk of childhood respiratory allergies: a sex-specific study.Respiratory research · 2020Article
- Maternal and cord blood vitamin D level and the infant gut microbiota in a birth cohort study.Maternal health, neonatology and perinatology · 2020Article
- Impact of parental asthma, prenatal maternal asthma control, and vitamin D status on risk of asthma and recurrent wheeze in 3-year-old children.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2019Article
- The association of maternal prenatal vitamin D levels and child current wheeze.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2018Article
- Serum 25-hydroxyvitamin D inversely associated with blood eosinophils in patients with persistent allergic rhinitis.Asia Pacific allergy · 2017Article
- The role of vitamin D in allergic rhinitis.Asia Pacific allergy · 2017Review
- Prenatal exposures and the development of childhood wheezing illnesses.Current opinion in allergy and clinical immunology · 2017Review
- Vitamin D in atopic dermatitis, chronic urticaria and allergic contact dermatitis.Expert review of clinical immunology · 2016Review
- Maternal-Cord Blood Vitamin D Correlations Vary by Maternal Levels.Journal of pregnancy · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundAllergy-related studies that include biological measurements of vitamin D preceding well-measured outcomes are needed.
objectiveWe sought to examine the associations between early-life vitamin D levels and the development of allergy-related outcomes in the racially diverse Wayne County Health, Environment, Allergy, and Asthma Longitudinal Study birth cohort.
methods25-Hydroxyvitamin D (25[OH]D) levels were measured in stored blood samples from pregnancy, cord blood, and age 2 years. Logistic regression models were used to calculate odds ratios (ORs) with 95% CIs for a 5 ng/mL increase in 25(OH)D levels for the following outcomes at age 2 years: eczema, skin prick tests (SPTs), increased allergen-specific IgE level (≥ 0.35 IU/mL), and doctor's diagnosis of asthma (3-6 years).
resultsPrenatal 25(OH)D levels were inversely associated with eczema (OR, 0.85; 95% CI, 0.75-0.96). The association was stronger in white children (white children: OR, 0.79; 95% CI, 0.57-1.09; black children: OR, 0.96; 95% CI, 0.82-1.12), although this was not statistically significant. Cord blood 25(OH)D levels were inversely associated with having 1 or more positive SPT responses and aeroallergen sensitization. Both associations were statistically significant in white children (positive SPT response: OR, 0.50; 95% CI, 0.32-0.80; ≥ 1 aeroallergen sensitization: OR, 0.50; 95% CI, 0.28-0.92) in contrast with black children (positive SPT response: OR, 0.88; 95% CI, 0.68-1.14; ≥ 1 aeroallergen sensitization: OR, 0.85; 95% CI, 0.65-1.11). 25(OH)D levels measured concurrently with outcome assessment were inversely associated with aeroallergen sensitization (OR, 0.79; 95% CI, 0.66-0.96) only among black children (white children: OR, 1.21; 95% CI, 0.87-1.69).
conclusionsPrenatal and cord blood 25(OH)D levels were associated with some allergy-related outcomes, with a general pattern indicating that children with higher 25(OH)D levels tend to have fewer allergy-related outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.