ReviewThe Journal of general physiology2015
Determinants of cation transport selectivity: Equilibrium binding and transport kinetics.
Review in The Journal of general physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Mechanism of SK2 channel gating and its modulation by the bee toxin apamin and small molecules.eLife · 2025Article
- Flexibility-Induced Collective Behavior Drives Symmetry Breaking in Discrimination of Undesired Ions.JACS Au · 2025Article
- Constitutive sodium permeability in aProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Ion behavior in the selectivity filter of HCN1 channels.Biophysical journal · 2022Article
- Physics of the Nuclear Pore Complex: Theory, Modeling and Experiment.Physics reports · 2021Article
- Thermodynamics of ion binding and occupancy in potassium channels.Chemical science · 2021Article
- Conductance selectivity of NaProceedings of the National Academy of Sciences of the United States of America · 2021Article
- The Archaeal NaFrontiers in chemistry · 2021Review
- A flexible filter maintains a tight grip.Nature chemical biology · 2019Article
- The permeation mechanism of organic cations through a CNG mimic channel.PLoS computational biology · 2018Article
- Cryo-EM and X-ray structures of TRPV4 reveal insight into ion permeation and gating mechanisms.Nature structural & molecular biology · 2018Article
- Article
- Structure-Functional Basis of Ion Transport in Sodium-Calcium Exchanger (NCX) Proteins.International journal of molecular sciences · 2016Review
- Pore size matters for potassium channel conductance.The Journal of general physiology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The crystal structures of channels and transporters reveal the chemical nature of ion-binding sites and, thereby, constrain mechanistic models for their transport processes. However, these structures, in and of themselves, do not reveal equilibrium selectivity or transport preferences, which can be discerned only from various functional assays. In this Review, I explore the relationship between cation transport protein structures, equilibrium binding measurements, and ion transport selectivity. The primary focus is on K(+)-selective channels and nonselective cation channels because they have been extensively studied both functionally and structurally, but the principles discussed are relevant to other transport proteins and molecules.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.