ArticleBMC cardiovascular disorders2015
Platelet volume indices are associated with systolic and diastolic cardiac dysfunction, and left ventricular hypertrophy.
Article in BMC cardiovascular disorders, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- Predictive value of platelet distribution width on organ damage in patients with metabolic syndrome: a retrospective case-control study.American journal of translational research · 2025Article
- Possible Correlations between Mean Platelet Volume and Biological, Electrocardiographic, and Echocardiographic Parameters in Patients with Heart Failure.Life (Basel, Switzerland) · 2024Article
- Association between postoperative nadir platelet count and postoperative cardiovascular complications following septal myectomy in patients with hypertrophic cardiomyopathy: a retrospective cohort study.BMC cardiovascular disorders · 2024Article
- Investigation of red blood cell and platelet indices in adult dogs suffered from myxomatous mitral valve disease with and without pulmonary hypertension.Frontiers in veterinary science · 2023Article
- Platelet volume indices correlate to severity of heart failure and have prognostic value for both cardiac and thrombotic events in patients with congenital heart disease.Heart and vessels · 2022Article
- Effects of clinical depression on left ventricular dysfunction in patients with acute coronary syndrome.Journal of thrombosis and thrombolysis · 2021Article
- High mean platelet volume to platelet count ratio as a predictor on poor outcomes after CABG.General thoracic and cardiovascular surgery · 2020Observational
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMean platelet volume (MPV) and platelet distribution width (PDW) are indices that reflect platelet activity. We investigated the association between these platelet indices and left ventricular hypertrophy and cardiac function.
methodsWe analyzed the data of 1241 patients who were admitted to the Cardiology Department.
resultsBoth MPV and PDW were selected as independent factors associated with left ventricular systolic and diastolic dysfunction, and left ventricular hypertrophy. The highest tertile of MPV and PDW was associated with left ventricular systolic dysfunction (left ventricular ejection fraction of <50 %) with an odds ratio of 1.53 and 2.03, respectively, when the respective lowest tertile was used as reference. The highest PDW tertile was associated with left ventricular hypertrophy with an odds ratio of 1.56 (95 % CI, 1.13-2.15) and with dysfunction with an odds ratio of 3.34 (95 % CI, 1.54-7.25).
conclusionsIndices of platelet activation (MPV and/or PDW) were independently associated positively with left ventricular hypertrophy and left ventricular systolic and diastolic dysfunction. Whether these platelet indices represent useful markers for identifying individuals at higher risk for thromboembolic disease and organ damage among cardiac patients awaits further investigation.
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