ArticleDrug development research2015
Effects of acute and sustained pain manipulations on performance in a visual-signal detection task of attention in rats.
Article in Drug development research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Factors mediating pain-related risk for opioid use disorder.Neuropharmacology · 2021Review
- Article
- Formalin-induced and neuropathic pain altered time estimation in a temporal bisection task in rats.Scientific reports · 2019Article
- Lactic acid suppresses IgE-mediated mast cell function in vitro and in vivo.Cellular immunology · 2019Article
- Core Outcome Measures in Preclinical Assessment of Candidate Analgesics.Pharmacological reviews · 2019Review
- Incisional Nociceptive Input Impairs Attention-related Behavior and Is Associated with Reduced Neuronal Activity in the Prefrontal Cortex in Rats.Anesthesiology · 2018Article
- Affect-Driven Attention Biases as Animal Welfare Indicators: Review and Methods.Animals : an open access journal from MDPI · 2018Review
- Intermittent stimulation in the nucleus basalis of meynert improves sustained attention in rhesus monkeys.Neuropharmacology · 2018Article
- Assessment of Behavioral Disruption in Rats with Abdominal Inflammation Using Visual Cue Titration and the Five-choice Serial-reaction Time Task.Anesthesiology · 2017Article
- Analysis of inflammation-induced depression of home cage wheel running in rats reveals the difference between opioid antinociception and restoration of function.Behavioural brain research · 2017Article
- Article
- Task- and Treatment Length-Dependent Effects of Vortioxetine on Scopolamine-Induced Cognitive Dysfunction and Hippocampal Extracellular Acetylcholine in Rats.The Journal of pharmacology and experimental therapeutics · 2016Article
- Home cage wheel running is an objective and clinically relevant method to assess inflammatory pain in male and female rats.Journal of neuroscience methods · 2016Article
- Evaluation of a Postoperative Pain-Like State on Motivated Behavior in Rats: Effects of Plantar Incision on Progressive-Ratio Food-Maintained Responding.Drug development research · 2015Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Preclinical Research Patients with pain often display cognitive impairment including deficits in attention. The visual-signal detection task (VSDT) is a behavioral procedure for assessment of attention in rodents. Male Sprague Dawley rats were trained in a VSDT and tested with three different noxious stimuli: (i) intraperitoneal injection of lactic acid; (ii) intraplantar injection of formalin; and (iii) intraplantar injection of complete Freund's adjuvant (CFA). The muscarinic acetylcholine receptor antagonist, scopolamine was also tested as a positive control. Scopolamine (0.01-1.0 mg/kg) dose dependently reduced accuracy and increased response latencies during completed trials with higher scopolamine doses increasing omissions. Lactic acid (0.56-5.6% ip) also increased response latencies and omissions, although it failed to alter measures of response accuracy. Formalin produced a transient decrease in accuracy while also increasing both response latency and omissions. CFA failed to alter VSDT performance. Although VSDT effects were transient for formalin and absent for CFA, both treatments produced mechanical allodynia and paw edema for up to 7 days. These results support the potential for noxious stimuli to produce a pain-related disruption of attention in rats. However, relatively strong noxious stimulation appears necessary to disrupt performance in this version of the VSDT.
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