ReviewTrends in microbiology2015
Bacterial cellulose biosynthesis: diversity of operons, subunits, products, and functions.
Review in Trends in microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 232 papers.
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Who cites it
232 citing papers in PubMed, 548 citations in OpenAlex.
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- Identification of Molecular Pathways Underlying Mn(II) Oxidation in Pseudomonas resinovorans.Environmental microbiology · 2026Article
- Bioengineering microbial cellulose synthesis pathways as biofactory for industrial-scale cellulose production: a review on current advances.World journal of microbiology & biotechnology · 2026Review
- Diverse Horizontally Transferred Cellulose Biosynthesis Gene Clusters inMicroorganisms · 2026Article
- CelluBase: a comprehensive genomic platform for advancing cellulose-producing bacteria.Microbial genomics · 2026Article
- Screening and optimisation of crude exopolysaccharide production by marine Brevibacterium sp. JAB08 isolated from the jellyfish Chrysaora sp. from the coastal waters of Goa.Antonie van Leeuwenhoek · 2026Article
- Phenotypic and Genomic Divergence in Biofilm Formation in STEC and Non-STECPathogens (Basel, Switzerland) · 2026Article
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- Wrinkle-like structures emerge from matrix complementarity and mechanical discontinuity in heterogenous biofilms.NPJ biofilms and microbiomes · 2026Article
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- Molecular mechanism underlying biofloc formation of Acidovorax soli Q11 and its application potential.Applied microbiology and biotechnology · 2026Article
- Comparative Genomics of High-Yielding Komagataeibacter diospyri Mutants Induced by Ultraviolet Light.Molecular biotechnology · 2026Article
- Peculiarities of Bacterial Cellulose.Polymers · 2026Review
- Characterization of bacterial nanocellulose cultivated on polyethylene terephthalate (PET) monomers via raman and fourier transform infrared spectroscopy.Scientific reports · 2026Article
- Rhizospheric glycosyltransferase repertoires as a resource for enabling sustainable bioprocessing and green biocatalyst discovery.Scientific reports · 2026Article
- Comparative Analysis of Lineage Structure, Cellulose Locus Context, and Mobilome Diversity Across CompleteMicroorganisms · 2026Article
- Plasmids of the multidrug-resistantMicrobiology spectrum · 2026Article
- Previously Uncharacterised Aliphatic Amino Acid Positions Modulate the Apparent Catalytic Activity of the EAL Domain of ZMO_1055 and Other Cyclic Di-GMP-Specific EAL Phosphodiesterases.Microbial biotechnology · 2026Article
- Bacterial Nanocellulose Functionalization for Smart Bioelectronics: Integration into Biosensing, Neural Interfaces, and Tissue Engineering.ACS polymers Au · 2025Review
- The Influence of Lipopolysaccharide O-Antigen Chain Length on Biofilm Formation Capacity and Outer Membrane Proteome Shape of Salmonella Enteritidis.Environmental microbiology reports · 2025Article
172 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Recent studies of bacterial cellulose biosynthesis, including structural characterization of a functional cellulose synthase complex, provided the first mechanistic insight into this fascinating process. In most studied bacteria, just two subunits, BcsA and BcsB, are necessary and sufficient for the formation of the polysaccharide chain in vitro. Other subunits - which differ among various taxa - affect the enzymatic activity and product yield in vivo by modulating (i) the expression of the biosynthesis apparatus, (ii) the export of the nascent β-D-glucan polymer to the cell surface, and (iii) the organization of cellulose fibers into a higher-order structure. These auxiliary subunits play key roles in determining the quantity and structure of resulting biofilms, which is particularly important for the interactions of bacteria with higher organisms - leading to rhizosphere colonization and modulating the virulence of cellulose-producing bacterial pathogens inside and outside of host cells. We review the organization of four principal types of cellulose synthase operon found in various bacterial genomes, identify additional bcs genes that encode components of the cellulose biosynthesis and secretion machinery, and propose a unified nomenclature for these genes and subunits. We also discuss the role of cellulose as a key component of biofilms and in the choice between acute infection and persistence in the host.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.