ArticleNeuroscience bulletin2015
Automated rapid iterative negative geotaxis assay and its use in a genetic screen for modifiers of Aβ(42)-induced locomotor decline in Drosophila.
Article in Neuroscience bulletin, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 44 citations in OpenAlex.
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- Design and Implementation of an Automated Drosophila Locomotor Assay Using Computer Vision Tracking.Research square · 2026Article
- Development, Characterization, and Evaluation of the Antidepressant Potential of Crocus sativus SLN Nasal Spray in a Drosophila melanogaster Model.Combinatorial chemistry & high throughput screening · 2026Article
- Differential effects of paraquat-induced oxidative stress on functional aging and lifespan in male and female Drosophila melanogaster.PloS one · 2026Article
- Icaritin greatly attenuates β-amyloid-induced toxicity in vivo.CNS neuroscience & therapeutics · 2024Article
- Jobelyn® extends the life span and improves motor function in Drosophila melanogaster exposed to lipopolysaccharide via augmentation of antioxidant status.Metabolic brain disease · 2022Article
- Animal Models of Neurodegenerative Disease: Recent Advances in Fly Highlight Innovative Approaches to Drug Discovery.Frontiers in molecular neuroscience · 2022Review
- Cannabinoids modulate food preference and consumption in Drosophila melanogaster.Scientific reports · 2021Article
- TheFrontiers in neuroscience · 2021Article
- Pgant4 and Tango1 Mediate Anoxia and Reoxygenation Injury.Neuroscience bulletin · 2020Article
- Amyloid-β peptides slightly affect lifespan or antimicrobial peptide gene expression in Drosophila melanogaster.BMC genetics · 2020Article
- Behavioral and molecular markers of death in Drosophila melanogaster.Experimental gerontology · 2019Article
- Reactivation of nonsense-mediated mRNA decay protects against C9orf72 dipeptide-repeat neurotoxicity.Brain : a journal of neurology · 2019Article
- Negative geotaxis: An early age behavioral hallmark to VPA rat model of autism.Annals of neurosciences · 2019Article
- An Efficient and Reliable Assay for Investigating the Effects of Hypoxia/Anoxia on Drosophila.Neuroscience bulletin · 2018Article
- An Automated Rapid Iterative Negative Geotaxis Assay for Analyzing Adult Climbing Behavior in a Drosophila Model of Neurodegeneration.Journal of visualized experiments : JoVE · 2017Article
- Composition and Control of a Deg/ENaC Channel during Presynaptic Homeostatic Plasticity.Cell reports · 2017Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The negative-geotaxis climbing assay is used to efficiently study aging and neurodegeneration in Drosophila. To make it suitable for large-scale study, a method called the rapid iterative negative geotaxis (RING) assay has been established by simultaneously photographing the climbing of multiple groups of flies when they are manually tapped down in test tubes. Here, we automated the assay by using a well-controlled electric motor to drive the tapping, and a homemade program to analyze the climbing height of flies. Using the automated RING (aRING) assay, we found that the climbing ability of a strain of wild-type flies, males in particular, declined rapidly before day 21 after eclosion, but slowly from day 21 to 35. We also found that the expression of arctic mutant Aβ42 accelerated the age-dependent decline in the climbing ability of flies. Moreover, using aRING, we examined the effect of third chromosome deficiencies on the accelerated locomotor decline in Aβ42-expressing flies, and isolated 7 suppressors and 15 enhancers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.