Evidence map›Paper›PMID 26077595›Full record

ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2015

A five year-old child with clear cell petro-clival meningioma: case report with clinical and histopathological long-term follow-up.

Tareq A Juratli, Kathrin D Geiger, Patrick Weigel, Maja von der Hagen, Dirk Daubner, Thomas Pinzer, Gabriele Hahn, Gabriele Schackert, Matthias Kirsch

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Paediatric supra- and infratentorial multiple giant clear cell meningioma: A report of a rare case and review of the literature.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021
    Review
  4. Article
  5. Pediatric intracranial clear cell meningioma: a clinicopathological study of seven cases and literature review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2017
    Review
  6. Suprasellar Clear Cell Meningioma in an Infant.Sultan Qaboos University medical journal · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Tareq A JuratliKlinik und Poliklinik für Neurochirurgie, Medizinische Fakultät Carl Gustav Carus, An der Technische Universität Dresden, Fetscherstrasse 74, 01307, Dresden, Germany. tareq.juratli@uniklinikum-dresden.de.
Kathrin D GeigerInstitut für Pathologie, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Patrick WeigelKlinik und Poliklinik für Neurochirurgie, Medizinische Fakultät Carl Gustav Carus, An der Technische Universität Dresden, Fetscherstrasse 74, 01307, Dresden, Germany.
Maja von der HagenAbteilung Neuropädiatrie, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Dirk DaubnerAbteilung für Neuroradiologie, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Thomas PinzerKlinik und Poliklinik für Neurochirurgie, Medizinische Fakultät Carl Gustav Carus, An der Technische Universität Dresden, Fetscherstrasse 74, 01307, Dresden, Germany.
Gabriele HahnInstitut und Poliklinik für Radiologische Diagnostik, Technische Universität Dresden, Dresden, Germany.
Gabriele SchackertKlinik und Poliklinik für Neurochirurgie, Medizinische Fakultät Carl Gustav Carus, An der Technische Universität Dresden, Fetscherstrasse 74, 01307, Dresden, Germany.
Matthias KirschKlinik und Poliklinik für Neurochirurgie, Medizinische Fakultät Carl Gustav Carus, An der Technische Universität Dresden, Fetscherstrasse 74, 01307, Dresden, Germany.
TU Dresden · DEKlinik und Poliklinik für Psychotherapie und Psychosomatik · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOnly a few cases have been previously published about clear cell meningiomas in children, the majority of them in the location of the spine. We describe an unusual case of clear cell meningioma occurring at the petro-clival region in a 5-year-old child. We further seek to determine the impact of several growth factors as well as the AKT1 mutation on the tumor growth pattern. CASE PRESENTATION: A five-year-old girl was presented with a one-week history of cephalgia, ataxia, and left sided torticollis. Magnetic resonance imaging (MRI) revealed a dumbbell-shaped homogeneously petro-clival gadolinium-enhancing mass. A staged operative approach was chosen, and a complete removal of the tumor was achieved. Due to recurrent tumor progression, the child underwent several tumor surgeries and two cranial radiations. None of the treatments were able to stop tumor progression. Consequently, the child died at the age of 14 after further extensive intracranial and extracranial tumor progression. The initial histological examination revealed a clear cell meningioma WHO grade II with an MIB-1 labeling index of <1%, which gradually increased with every recurrence up to 10% by the last progression at the age of 13 years. Analogically, an increasing overexpression of epidermal growth factor receptor (EGFR), the platelet-derived growth factor receptor (PDGFR), and the vascular endothelial growth factor receptor (VEGFR) was observed with each recurrence. The AKT1 (E17K) mutation in the tumor was not detectable in all investigated specimens.

conclusionPediatric clear cell meningiomas WHO grade II are very rare. Our data demonstrate the progressive overexpression of EGF-, PDGF-, and VEGF-receptors in each recurrence, providing one of these receptors as targeted therapy in such cases. Further evaluation of these growth factors in clear cell meningioma is required to establish the optimal treatment of these aggressive tumors.

Indexed as

BrainChild, PreschoolErbB ReceptorsFemaleHumansLongitudinal StudiesMagnetic Resonance ImagingMeningeal NeoplasmsMeningiomaMutationProto-Oncogene Proteins c-aktReceptor, Platelet-Derived Growth Factor alphaReceptors, Vascular Endothelial Growth FactorAKT1 protein, humanErbB ReceptorsProto-Oncogene Proteins c-aktReceptor, Platelet-Derived Growth Factor alphaReceptors, Vascular Endothelial Growth FactorAKT1 mutationChildClear cell meningiomaEpidermal growth factor receptorPlatelet-derived growth factor receptorVascular endothelial growth factor receptor

Identifiers

PMID26077595
OpenAlexW570850148

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.