Evidence map›Paper›PMID 26077590›Full record

ArticleJournal of the American Heart Association2015

Magnetic resonance angiography detection of abnormal carotid artery plaque in patients with cryptogenic stroke.

Ajay Gupta, Gino Gialdini, Michael P Lerario, Hediyeh Baradaran, Ashley Giambrone, Babak B Navi, Randolph S Marshall, Costantino Iadecola, Hooman Kamel

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Heart Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 4 pooled it
8.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 4 syntheses or guidelines pooled it, 100 citations in OpenAlex.

  1. Pooled it
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  10. The role of non-stenosing carotid artery plaques in embolic stroke of undetermined source, is it a silent offender? A review of literature.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2024
    Review
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  18. Evaluation of non-stenotic carotid atherosclerotic plaques with combined FDG-PET imaging and CT angiography in patients with ischemic stroke of unknown origin.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Ajay GuptaDepartment of Radiology, Weill Cornell Medical College (WCMC), New York, NY (A.G., H.B.) Feil Family Brain and Mind Research Institute, Weill Cornell Medical College (WCMC), New York, NY (A.G., G.G., B.B.N., C.I., H.K.).
Gino GialdiniFeil Family Brain and Mind Research Institute, Weill Cornell Medical College (WCMC), New York, NY (A.G., G.G., B.B.N., C.I., H.K.).
Michael P LerarioDepartment of Neurology, Weill Cornell Medical College (WCMC), New York, NY (M.P.L., B.B.N., C.I., H.K.).
Hediyeh BaradaranDepartment of Radiology, Weill Cornell Medical College (WCMC), New York, NY (A.G., H.B.).
Ashley GiambroneDepartment of Healthcare Policy and Research, Weill Cornell Medical College (WCMC), New York, NY (A.G.).
Babak B NaviDepartment of Neurology, Weill Cornell Medical College (WCMC), New York, NY (M.P.L., B.B.N., C.I., H.K.) Feil Family Brain and Mind Research Institute, Weill Cornell Medical College (WCMC), New York, NY (A.G., G.G., B.B.N., C.I., H.K.).
Randolph S MarshallDepartment of Neurology, Columbia University Medical Center, New York, NY (R.S.M.).
Costantino IadecolaDepartment of Neurology, Weill Cornell Medical College (WCMC), New York, NY (M.P.L., B.B.N., C.I., H.K.) Feil Family Brain and Mind Research Institute, Weill Cornell Medical College (WCMC), New York, NY (A.G., G.G., B.B.N., C.I., H.K.).
Hooman KamelDepartment of Neurology, Weill Cornell Medical College (WCMC), New York, NY (M.P.L., B.B.N., C.I., H.K.) Feil Family Brain and Mind Research Institute, Weill Cornell Medical College (WCMC), New York, NY (A.G., G.G., B.B.N., C.I., H.K.).
Cornell University · USMIND Research Institute · USColumbia University Irving Medical Center · US

Funding

NO SYNTHASE GENE EXPRESSION AND CEREBRAL ISCHEMIC DAMAGER01NS034179 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI IADECOLA, COSTANTINO · 1995 to 2021
$5.5M
Atrial Fibrillation Precursors May Be Novel Stroke Risk FactorsK23NS082367 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI KAMEL, HOOMAN · 2013 to 2017
$937k
NINDS NIH HHS K23 NS082367NINDS NIH HHS K23NS082367NINDS NIH HHS R01 NS034179
6 · The paper itself

Abstract

backgroundMagnetic resonance imaging of carotid plaque can aid in stroke risk stratification in patients with carotid stenosis. However, the prevalence of complicated carotid plaque in patients with cryptogenic stroke is uncertain, especially as assessed by plaque imaging techniques routinely included in acute stroke magnetic resonance imaging protocols. We assessed whether the magnetic resonance angiography-defined presence of intraplaque high-intensity signal (IHIS), a marker of intraplaque hemorrhage, is associated with ipsilateral cryptogenic stroke. METHODS AND

resultsCryptogenic stroke patients with magnetic resonance imaging evidence of unilateral anterior circulation infarction and without hemodynamically significant (≥50%) stenosis of the cervical carotid artery were identified from a prospective stroke registry at a tertiary-care hospital. High-risk plaque was assessed by evaluating for IHIS on routine magnetic resonance angiography source images using a validated technique. To compare the presence of IHIS on the ipsilateral versus contralateral side within individual patients, we used McNemar's test for correlated proportions. A total of 54 carotid arteries in 27 unique patients were included. A total of 6 patients (22.2%) had IHIS-positive nonstenosing carotid plaque ipsilateral to the side of ischemic stroke compared to 0 patients who had IHIS-positive carotid plaques contralateral to the side of stroke (P=0.01). Stroke severity measures, diagnostic evaluations, and prevalence of vascular risk factors were not different between the IHIS-positive and IHIS-negative groups.

conclusionsOur findings suggest that a proportion of strokes classified as cryptogenic may be mechanistically related to complicated, nonhemodynamically significant cervical carotid artery plaque that can easily be detected by routine magnetic resonance imaging/magnetic resonance angiography acute stroke protocols.

Indexed as

Magnetic Resonance AngiographyAgedAged, 80 and overCarotid ArteriesCarotid StenosisFemaleHumansMaleStrokecarotid arterycryptogenic strokemagnetic resonance angiographymagnetic resonance imagingrisk factorstroke

Identifiers

PMID26077590
PMCPMC4599540
OpenAlexW2145452392

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.