Trial reportJournal of the American Heart Association2015
Edge-detected common carotid artery intima-media thickness and incident coronary heart disease in the multi-ethnic study of atherosclerosis.
Trial report in Journal of the American Heart Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00063440 (Epidemiology of Carotid IMT Progression in MESA - Ancillary Study), which is not on this map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Epidemiology of Carotid IMT Progression in MESA - Ancillary Study
Who cites it
10 citing papers in PubMed, 23 citations in OpenAlex.
- Correlation of blood lipid parameters with newly diagnosed carotid intima media thickness and carotid plaque in primary health care of populations.Frontiers in cardiovascular medicine · 2026Article
- Natural History of Atherosclerosis and Abdominal Aortic Intima-Media Thickness: Rationale, Evidence, and Best Practice for Detection of Atherosclerosis in the Young.Journal of clinical medicine · 2019Review
- Cardiovascular markers of inflammation and serum lipid levels in HIV-infected patients with undetectable viremia.Scientific reports · 2018Article
- Risk factors and utility of maximum carotid intima-media thickness as a surrogate marker for coronary artery stenosis.Therapeutics and clinical risk management · 2018Article
- Post-processing reproducibility of the structural characteristics of the common carotid artery in a Flemish population.Artery research · 2017Article
- Carotid plaque-thickness and common carotid IMT show additive value in cardiovascular risk prediction and reclassification.Atherosclerosis · 2017Article
- Article
- Radioiodine Therapy Does Not Change the Atherosclerotic Burden of the Carotid Arteries.Thyroid : official journal of the American Thyroid Association · 2016Article
- Current status of carotid ultrasound in atherosclerosis.Quantitative imaging in medicine and surgery · 2016Review
- HIV related stigma, perceived social support and risk of premature atherosclerosis in South Asians.Indian heart journalArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundCommon carotid artery intima-media thickness (IMT) can be measured either by hand or with an automated edge detector. We performed a direct comparison of these 2 approaches and studied their respective associations with coronary heart disease outcomes. METHODS AND
resultsWe studied 5468 participants of the Multi-Ethnic Study of Atherosclerosis, composed of white, Chinese, Hispanic, and black participants with an average age of 61.9 years (47.8% men) and who were free of coronary heart disease at baseline. Manual-traced and edge-detected IMT measurements were made in the same location on ultrasound images of the right common carotid artery far wall in an area free of plaque. Manual-traced and edge-detected common carotid artery IMT measurements were added separately to multivariable Cox proportional hazards models with time to incident coronary heart disease as the outcome and adjusted for traditional coronary heart disease Framingham risk factors, lipid-lowering therapy, blood pressure-lowering therapy, and race or ethnicity. Additional models were generated after adding clinic site and reader. There were 349 events during a median follow-up of 10.2 years. In adjusted models, the hazard ratio was not significant (1.31; 95% CI 0.84 to 2.06) for each millimeter increase in manual-traced IMT but was significant for edge-detected IMT (hazard ratio 1.63; 95% CI 1.12 to 2.37). Edge-detected IMT remained statistically associated with outcomes after additional adjustment for clinic site and reader performing the IMT measurement (hazard ratio 1.59; 95% CI 1.07 to 2.35).
conclusionsEdge-detected common carotid artery far wall IMT has similar if not stronger associations with coronary heart disease outcomes when compared with manual-traced IMT. CLINICAL
trial registrationURL: https://www.clinicaltrials.gov/. Unique identifier: NCT00063440.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.