ArticleEJNMMI research2015
A new compartmental method for the analysis of liver FDG kinetics in small animal models.
Article in EJNMMI research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 31 citations in OpenAlex.
- Localized FDG loss in lung cancer lesions.EJNMMI research · 2024Article
- Mathematical Models for FDG Kinetics in Cancer: A Review.Metabolites · 2021Review
- Article
- FDG uptake tracks the oxidative damage in diabetic skeletal muscle: An experimental study.Molecular metabolism · 2020Article
- Structural and practical identifiability of dual-input kinetic modeling in dynamic PET of liver inflammation.Physics in medicine and biology · 2019Article
- G6Pase location in the endoplasmic reticulum: Implications on compartmental analysis of FDG uptake in cancer cells.Scientific reports · 2019Article
- Kinetic Analysis of Hepatic Metabolism Using Hyperpolarized Dihydroxyacetone.Journal of chemical information and modeling · 2019Article
- Anthropometric and glucometabolic changes in an aged mouse model of lipocalin-2 overexpression.International journal of obesity (2005) · 2019Article
- Dynamic PET of human liver inflammation: impact of kinetic modeling with optimization-derived dual-blood input function.Physics in medicine and biology · 2018Article
- Searching for novel PET radiotracers: imaging cardiac perfusion, metabolism and inflammation.American journal of nuclear medicine and molecular imaging · 2018Review
- Positron emission tomography and single photon emission computed tomography imaging of tertiary lymphoid structures during the development of lupus nephritis.International journal of immunopathology and pharmacologyArticle
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCompartmental analysis is a standard method to quantify metabolic processes using fluorodeoxyglucose-positron emission tomography (FDG-PET). For liver studies, this analysis is complex due to the hepatocyte capability to dephosphorylate and release glucose and FDG into the blood. Moreover, a tracer is supplied to the liver by both the hepatic artery and the portal vein, which is not visible in PET images. This study developed an innovative computational approach accounting for the reversible nature of FDG in the liver and directly computing the portal vein tracer concentration by means of gut radioactivity measurements.
methodsTwenty-one mice were subdivided into three groups: the control group 'CTR' (n = 7) received no treatment, the short-term starvation group 'STS' (n = 7) was submitted to food deprivation with free access to water within 48 h before imaging, and the metformin group 'MTF' (n = 7) was treated with metformin (750 mg/Kg per day) for 1 month. All mice underwent a dynamic micro-PET study for 50 min after an (18)F-FDG injection. The compartmental analysis considered two FDG pools (phosphorylated and free) in both the gut and liver. A tracer was carried into the liver by the hepatic artery and the portal vein, and tracer delivery from the gut was considered as the sole input for portal vein tracer concentration. Accordingly, both the liver and gut were characterized by two compartments and two exchange coefficients. Each one of the two two-compartment models was mathematically described by a system of differential equations, and data optimization was performed by applying a Newton algorithm to the inverse problems associated to these differential systems.
resultsAll rate constants were stable in each group. The tracer coefficient from the free to the metabolized compartment in the liver was increased by STS, while it was unaltered by MTF. By contrast, the tracer coefficient from the metabolized to the free compartment was reduced by MTF and increased by STS.
conclusionsData demonstrated that our method was able to analyze FDG kinetics under pharmacological or pathophysiological stimulation, quantifying the fraction of the tracer trapped in the liver or dephosphorylated and released into the bloodstream.
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