ArticleMagnetic resonance in medicine2016
Multi-spin echo spatial encoding provides three-fold improvement of temperature precision during intermolecular zero quantum thermometry.
Article in Magnetic resonance in medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 10 citations in OpenAlex.
- Magnetic resonance temperature imaging of laser-induced thermotherapy using proton resonance frequency shift: evaluation of different sequences in phantom and porcine brain at 7 T.Japanese journal of radiology · 2022Article
- Contactless Thermometry by MRI and MRS: Advanced Methods for Thermotherapy and Biomaterials.iScience · 2020Review
- Magnetic resonance thermometry and its biological applications - Physical principles and practical considerations.Progress in nuclear magnetic resonance spectroscopy · 2019Review
- Correlation distance dependence of the resonance frequency of intermolecular zero quantum coherences and its implication for MR thermometry.Magnetic resonance in medicine · 2018Article
- Remote detection of hyperpolarizedThe Journal of chemical physics · 2016Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
purposeIntermolecular multiple quantum coherences (iMQCs) are a source of MR contrast with applications including temperature imaging, anisotropy mapping, and brown fat imaging. Because all applications are limited by signal-to-noise ratio (SNR), we developed a pulse sequence that detects intermolecular zero quantum coherences with improved SNR.
methodsA previously developed pulse sequence that detects iMQCs, HOMOGENIZED with off resonance transfer (HOT), was modified with a multi-spin echo spatial encoding scheme (MSE-HOT). MSE-HOT uses a series of refocusing pulses to generate a stack of images that are averaged in postprocessing for higher SNR. MSE-HOT performance was quantified by measuring its temperature accuracy and precision during hyperthermia of ex vivo red bone marrow samples.
resultsMSE-HOT yielded a three-fold improvement in temperature precision relative to previous pulse sequences. Sources of improved precision were 1) echo averaging and 2) suppression of J-coupling in the methylene protons of fat. MSE-HOT measured temperature change with an accuracy of 0.6°C.
conclusionMSE-HOT improved the temperature accuracy and precision of HOT to a level that is sufficient for hyperthermia of bone marrow.
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