ArticleThe Journal of physiology2016
Magnesium sulphate and cardiovascular and cerebrovascular adaptations to asphyxia in preterm fetal sheep.
Article in The Journal of physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- A Systematic Review of Magnesium Sulfate for Perinatal Neuroprotection: What Have We Learnt From the Past Decade?Frontiers in neurology · 2020Pooled it
- Fetal and neonatal brain protection at term-The role of translational experimental models.Acta obstetricia et gynecologica Scandinavica · 2026Article
- Does MgSO4 protect the preterm brain? Dissecting its role in the pathophysiology of hypoxic ischemic encephalopathy.Neural regeneration research · 2024Article
- Magnesium sulphate reduces tertiary gliosis but does not improve EEG recovery or white or grey matter cell survival after asphyxia in preterm fetal sheep.The Journal of physiology · 2023Article
- Interleukin-1 blockade attenuates white matter inflammation and oligodendrocyte loss after progressive systemic lipopolysaccharide exposure in near-term fetal sheep.Journal of neuroinflammation · 2021Article
- Cerebral blood volume increment after resuscitation measured by near-infrared time-resolved spectroscopy can estimate degree of hypoxic-ischemic insult in newborn piglets.Scientific reports · 2021Article
- Time and sex dependent effects of magnesium sulphate on post-asphyxial seizures in preterm fetal sheep.The Journal of physiology · 2018Article
- The fetus at the tipping point: modifying the outcome of fetal asphyxia.The Journal of physiology · 2018Review
- Antenatal prevention of cerebral palsy and childhood disability: is the impossible possible?The Journal of physiology · 2018Review
- Experimental and clinical evidence of differential effects of magnesium sulfate on neuroprotection and angiogenesis in the fetal brain.Pharmacology research & perspectives · 2017Article
- Magnesium sulfate reduces EEG activity but is not neuroprotective after asphyxia in preterm fetal sheep.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2017Article
- Sex, drugs and rock and roll: tales from preterm fetal life.The Journal of physiology · 2017Review
- Cerebral economics: shedding light on supply and demand in the developing brain.The Journal of physiology · 2017Article
- Use of magnesium sulfate before 32 weeks of gestation: a European population-based cohort study.BMJ open · 2017Article
- Antenatal Exposure to Magnesium Sulfate Is Associated with Reduced Cerebellar Hemorrhage in Preterm Newborns.The Journal of pediatrics · 2016Article
- The myths and physiology surrounding intrapartum decelerations: the critical role of the peripheral chemoreflex.The Journal of physiology · 2016Review
- Hypoxia, fetal and neonatal physiology: 100 years on from Sir Joseph Barcroft.The Journal of physiology · 2016Article
- Perinatal neuroprotection update.F1000Research · 2016Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Magnesium sulphate is a standard therapy for eclampsia in pregnancy and is widely recommended for perinatal neuroprotection during threatened preterm labour. MgSO4 is a vasodilator and negative inotrope. Therefore the aim of this study was to investigate the effect of MgSO4 on the cardiovascular and cerebrovascular responses of the preterm fetus to asphyxia. Fetal sheep were instrumented at 98 ± 1 days of gestation (term = 147 days). At 104 days, unanaesthetised fetuses were randomly assigned to receive an intravenous infusion of MgSO4 (n = 6) or saline (n = 9). At 105 days all fetuses underwent umbilical cord occlusion for 25 min. Before occlusion, MgSO4 treatment reduced heart rate and increased femoral blood flow (FBF) and vascular conductance compared to controls. During occlusion, carotid and femoral arterial conductance and blood flows were higher in MgSO4-treated fetuses than controls. After occlusion, fetal heart rate was lower and carotid and femoral arterial conductance and blood flows were higher in MgSO4-treated fetuses than controls. Femoral arterial waveform height and width were increased during MgSO4 infusion, consistent with increased stroke volume. MgSO4 did not alter the fetal neurophysiological or nuchal electromyographic responses to asphyxia. These data demonstrate that a clinically comparable dose of MgSO4 increased FBF and stroke volume without impairing mean arterial pressure (MAP) or carotid blood flow (CaBF) during and immediately after profound asphyxia. Thus, MgSO4 may increase perfusion of peripheral vascular beds during adverse perinatal events.
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