ArticleJournal of clinical oncology : official journal of the American Society of Clinical Oncology2015
Elevated Cancer-Specific Mortality Among HIV-Infected Patients in the United States.
Article in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 207 papers, 8 of them syntheses that pooled it.
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Who cites it
207 citing papers in PubMed, 8 syntheses or guidelines pooled it.
- Immune-related conditions and cancer-specific mortality among older adults with cancer in the United States.International journal of cancer · 2022Pooled it
- Immune correlates of therapy outcomes in women with cervical cancer treated with chemoradiotherapy: A systematic review.Cancer medicine · 2021Pooled it
- Risk of prostate cancer in men with HIV/AIDS: a systematic review and meta-analysis.Prostate cancer and prostatic diseases · 2021Pooled it
- Cancer disparities in people with HIV: A systematic review of screening for non-AIDS-defining malignancies.Cancer · 2019Pooled it
- Anal Carcinoma, Version 2.2018, NCCN Clinical Practice Guidelines in Oncology.Journal of the National Comprehensive Cancer Network : JNCCN · 2018Guideline
- Human immunodeficiency virus infection and mortality risk among lung cancer patients: A systematic review and meta-analysis.Medicine · 2018Pooled it
- HIV-positive women have higher risk of human papilloma virus infection, precancerous lesions, and cervical cancer.AIDS (London, England) · 2018Pooled it
- Risk of Colorectal Cancer and Associated Mortality in HIV: A Systematic Review and Meta-Analysis.Journal of acquired immune deficiency syndromes (1999) · 2017Pooled it
- Participant characteristics and clinical trial decision-making factors in AIDS malignancy consortium treatment trials for HIV-infected persons with cancer (AMC #S006).HIV clinical trials · 2018Trial
- Cetuximab Plus Chemoradiotherapy for HIV-Associated Anal Carcinoma: A Phase II AIDS Malignancy Consortium Trial.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2017Trial
- Feasibility of interim positron emission tomography (PET)-adapted therapy in HIV-positive patients with advanced Hodgkin lymphoma (HL): a sub-analysis of SWOG S0816 Phase 2 trial.Leukemia & lymphoma · 2017Trial
- Cancer Screening Behaviors among People with HIV in the United States and the Role of Multi-Level Social and Economic Factors: A Systematic Review.Current epidemiology reports · 2026Article
- Manipulation of the cell cycle by HIV-1.Biochemical Society transactions · 2026Review
- Associations Between HIV Infection Status, Psychosocial Factors, and Adjuvant Endocrine Therapy Adherence Among South African Women with Stage I-III Breast Cancer.International journal of behavioral medicine · 2026Article
- Predictors of anal and cervical cancer screening uptake among adults with and without HIV: survey of a community-based health clinic network.Cancer causes & control : CCC · 2026Article
- Rates and Outcomes of Head and Neck Cancer Among Patients With Primary Immunodeficiency Disorders.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2026Article
- Mortality risk in patients with urological malignancies and human immunodeficiency virus (HIV) coinfection: A systematic review and meta-analysis of cohort studies.Cancer pathogenesis and therapy · 2026Review
- HIV Seroprevalence and Screening Practices Among Cancer Patients Receiving Immune Checkpoint Inhibitors: A Single-Center Study From Türkiye.Journal of clinical practice and research · 2026Article
- Progression Risk in Cancer Patients with HIV Compared with Cancer Patients Without HIV.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026Observational
- HIV infection and survival in Hodgkin lymphoma: a real-world analysis of a multicenter research network.JNCI cancer spectrum · 2026Article
147 more citing papers are in PubMed but not listed here.
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Funding
Abstract
purposeDespite advances in the treatment of HIV, HIV-infected people remain at increased risk for many cancers, and the number of non-AIDS-defining cancers is increasing with the aging of the HIV-infected population. No prior study has comprehensively evaluated the effect of HIV on cancer-specific mortality. PATIENTS AND
methodsWe identified cases of 14 common cancers occurring from 1996 to 2010 in six US states participating in a linkage of cancer and HIV/AIDS registries. We used Cox regression to examine the association between patient HIV status and death resulting from the presenting cancer (ascertained from death certificates), adjusting for age, sex, race/ethnicity, year of cancer diagnosis, and cancer stage. We included 1,816,461 patients with cancer, 6,459 (0.36%) of whom were HIV infected.
resultsCancer-specific mortality was significantly elevated in HIV-infected compared with HIV-uninfected patients for many cancers: colorectum (adjusted hazard ratio [HR], 1.49; 95% CI, 1.21 to 1.84), pancreas (HR, 1.71; 95% CI, 1.35 to 2.18), larynx (HR, 1.62; 95% CI, 1.06 to 2.47), lung (HR, 1.28; 95% CI, 1.17 to 1.39), melanoma (HR, 1.72; 95% CI, 1.09 to 2.70), breast (HR, 2.61; 95% CI, 2.06 to 3.31), and prostate (HR, 1.57; 95% CI, 1.02 to 2.41). HIV was not associated with increased cancer-specific mortality for anal cancer, Hodgkin lymphoma, or diffuse large B-cell lymphoma. After further adjustment for cancer treatment, HIV remained associated with elevated cancer-specific mortality for common non-AIDS-defining cancers: colorectum (HR, 1.40; 95% CI, 1.09 to 1.80), lung (HR, 1.28; 95% CI, 1.14 to 1.44), melanoma (HR, 1.93; 95% CI, 1.14 to 3.27), and breast (HR, 2.64; 95% CI, 1.86 to 3.73).
conclusionHIV-infected patients with cancer experienced higher cancer-specific mortality than HIV-uninfected patients, independent of cancer stage or receipt of cancer treatment. The elevation in cancer-specific mortality among HIV-infected patients may be attributable to unmeasured stage or treatment differences as well as a direct relationship between immunosuppression and tumor progression.
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