ArticleBMC nephrology2015
Risk factors and their interaction on chronic kidney disease: A multi-centre case control study in Taiwan.
Article in BMC nephrology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Sexually dimorphic response to tobacco in the development of chronic kidney disease: a systematic review.BMC nephrology · 2024Pooled it
- Hepatitis B virus infection as a risk factor for chronic kidney disease: a systematic review and meta-analysis.BMC infectious diseases · 2024Pooled it
- Betel nut chewing and the risk of chronic kidney disease: evidence from a meta-analysis.International urology and nephrology · 2018Pooled it
- Review
- Clinical risk factors associated with rapid renal function decline after nephrectomy.BMC cancer · 2026Article
- Research advances in the etiology of in-stent restenosis of coronary arteries.Frontiers in cardiovascular medicine · 2025Review
- Mitochondrial DNA copy number is associated with incident chronic kidney disease and proteinuria in the AIDS linked to the intravenous experience cohort.Scientific reports · 2023Article
- Betel Nut Chewing Is Associated with the Risk of Kidney Stone Disease.Journal of personalized medicine · 2022Article
- Sedentarism, A Modifiable Risk Factor for Developing Chronic Kidney Disease in Healthy People.Korean journal of family medicine · 2022Article
- Hyperuricemia, urate-lowering therapy, and kidney outcomes: a systematic review and meta-analysis.Therapeutic advances in musculoskeletal disease · 2021Article
- Diabetes, Hypertension, and Incidence of Chronic Kidney Disease: Is There any Multiplicative or Additive Interaction?International journal of endocrinology and metabolism · 2021Article
- Supervised Exercise Intervention and Overall Activity in CKD.Kidney international reports · 2020Article
- Risk Factors for End-Stage Renal Failure Among Patients on Hemodialysis in Aljomhory Hospital, Sa'adah Governorate, Yemen: Hospital-Based Case-Control Study.JMIR public health and surveillance · 2019Article
- The association of exercise and sedentary behaviours with incident end-stage renal disease: the Southern Community Cohort Study.BMJ open · 2019Article
- Diabetic Retinopathy as a Risk Factor for Chronic Kidney Disease Progression: A Multicenter Case⁻Control Study in Taiwan.Nutrients · 2019Article
- Application of survival tree analysis for exploration of potential interactions between predictors of incident chronic kidney disease: a 15-year follow-up study.Journal of translational medicine · 2017Article
- Possible combinatorial effects of current smoking and alcohol intake on chronic kidney disease in a Japanese nationwide cross-sectional survey.Hypertension research : official journal of the Japanese Society of Hypertension · 2017Article
- Estimating One-Year Risk of Incident Chronic Kidney Disease: Retrospective Development and Validation Study Using Electronic Medical Record Data From the State of Maine.JMIR medical informatics · 2017Article
- Advances in Chronic Kidney Disease.International journal of molecular sciences · 2016Article
- Soy-based renoprotection.World journal of nephrology · 2016Review
Corrections and comments
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Authors and funding
21 authors at 11 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChronic kidney disease (CKD) is highly prevalent in Taiwan. More than two-thirds of end-stage renal disease is associated with diabetes mellitus (DM) or hypertension (HTN). Therefore, the formulation of a special preventative policy of CKD in these patients is essential. This study surveyed 14 traditional risk factors and identified their effects on CKD in patients with HTN/DM and compared these with their effects in the general population.
methodsThis study included 5328 cases and 5135 controls in the CKD/HTN/DM outpatient and health centres of 10 hospitals from 2008 to 2010. Fourteen common effect factors were surveyed (four demographic, five disease and five lifestyle), and their effects on CKD were tested. Significance tests were adjusted by the Bonferroni method. Results of the stratified analyses in the variables were presented with significant heterogeneity between patients with different comorbidities.
resultsMale, ageing, low income, hyperuricemia and lack of exercise habits were risk factors for CKD, and their effects in people with different comorbidities were identical. Anaemia was a risk factor, and there was an additive effect between anaemia and HTN on CKD. Patients with anaemia had a higher risk when associated with HTN [odds ratio (OR) = 6.75, 95% confidence limit (95% CI) 4.76-9.68] but had a smaller effect in people without HTN (OR 2.83, 95% CI 2.16-3.67). The association between hyperlipidaemia-related factors and CKD was also moderated by HTN. It was a significant risk factor in people without HTN (OR = 1.67, 95% CI 1.38-2.01) but not in patients with HTN (OR =1.03, 95% CI 0.89-1.19). Hepatitis B, hepatitis C, betel nut chewing, smoking, alcohol intake and groundwater use were not associated with CKD in multivariate analysis.
conclusionsWe considered that patients with HTN and anaemia were a high CKD risk population. Physicians with anaemic patients in outpatient clinics need to recognise that patients who also have HTN might be latent CKD cases.
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