ArticleIntensive care medicine2015
Early fluid accumulation in children with shock and ICU mortality: a matched case-control study.
Article in Intensive care medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 3 of them syntheses that pooled it.
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Who cites it
36 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Association between fluid overload and mortality in children with sepsis: a systematic review and meta-analysis.BMJ paediatrics open · 2023Pooled it
- Association Between Fluid Balance and Outcomes in Critically Ill Children: A Systematic Review and Meta-analysis.JAMA pediatrics · 2018Pooled it
- Conservative fluid management or deresuscitation for patients with sepsis or acute respiratory distress syndrome following the resuscitation phase of critical illness: a systematic review and meta-analysis.Intensive care medicine · 2017Pooled it
- Restricted fluid bolus volume in early septic shock: results of the Fluids in Shock pilot trial.Archives of disease in childhood · 2019Trial
- Early inotropic support without fluid bolusWorld journal of clinical pediatrics · 2026Article
- Necrotising enterocolitis suspicion in newborns with duct-dependent congenital heart disease: prognosis and risk factor.BMJ paediatrics open · 2024Article
- The effect of high-volume intraoperative fluid administration on outcomes among pediatric patients undergoing living donor liver transplantation.BMC surgery · 2024Article
- Fluid assessment, fluid balance, and fluid overload in sick children: a report from the Pediatric Acute Disease Quality Initiative (ADQI) conference.Pediatric nephrology (Berlin, Germany) · 2024Article
- Article
- Nutritional management of children with acute kidney injury-clinical practice recommendations from the Pediatric Renal Nutrition Taskforce.Pediatric nephrology (Berlin, Germany) · 2023Review
- Fluid Balance and Its Association With Mortality and Health-Related Quality of Life: A Nonprespecified Secondary Analysis of the Life After Pediatric Sepsis Evaluation.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2023Article
- Clinical characteristics and outcomes of continuous renal replacement therapy performed on younger children weighing up to 10 kg.Turkish journal of medical sciences · 2023Observational
- Fluid bolus therapy in pediatric sepsis: a narrative review.European journal of medical research · 2022Review
- Paediatric dengue shock syndrome and acute respiratory failure: a single-centre retrospective study.BMJ paediatrics open · 2022Article
- Prospective Cohort Study on Cumulative Fluid Balance and Outcome in Critically Ill Children Using a Restrictive Fluid Protocol.Indian journal of pediatrics · 2022Article
- Examining the Relationship between Depression, Anxiety and Stress in Kidney Cancer Patients.Journal of kidney cancer and VHL · 2022Article
- Association between early fluid overload and mortality in critically-ill mechanically ventilated children: a single-center retrospective cohort study.BMC pediatrics · 2021Article
- Positive fluid balance is associated with death and severity of brain injury in neonates with hypoxic-ischemic encephalopathy.Journal of perinatology : official journal of the California Perinatal Association · 2021Observational
- Infectious Diseases Society of America Position Paper: Recommended Revisions to the National Severe Sepsis and Septic Shock Early Management Bundle (SEP-1) Sepsis Quality Measure.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- ICU admission following an unscheduled return visit to the pediatric emergency department within 72 hours.BMC pediatrics · 2019Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe purpose of this study was to evaluate the association between early fluid accumulation and mortality in children with shock states.
methodsWe retrospectively reviewed children admitted in shock states to the pediatric intensive care unit (ICU) at a tertiary level children's hospital over a 7-month period. The study was designed as a matched case-control study. Children with early fluid overload, defined as fluid accumulation of ≥10% of admission body weight during the initial 3 days, were designated as the cases. They were compared with matched controls without early fluid accumulation. Cases and controls were matched for age, severity of illness at ICU admission and need for organ support. They were compared with respect to all-cause ICU mortality and other secondary outcomes.
resultsA total of 114 children (age range 0-17.4 years; N = 42 cases and 72 matched controls) met the study criteria. Mortality rate was 13% (15/114) in this cohort. Multivariable logistic regression analysis identified the presence of early fluid overload [adjusted odds ratio (OR) 9.17, 95% confidence interval (CI) 2.22-55.57], its severity (adjusted OR 1.11, 95% CI 1.05-1.19) and its duration (adjusted OR 1.61, 95% CI 1.21-2.28) as independent predictors of mortality. Cases had higher mortality than the controls (26 vs. 6 %; p 0.003), and this difference remained significant in the matched analysis (37 vs. 3%; p 0.002).
conclusionThe presence, severity and duration of early fluid are associated with increased ICU mortality in children admitted to the pediatric ICU in shock states.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.