ArticleScientific reports2015
Aspartate Decarboxylase is Required for a Normal Pupa Pigmentation Pattern in the Silkworm, Bombyx mori.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 37 citations in OpenAlex.
- Insect-specific aldehyde synthase governs cuticle strength: a selective insecticide target.Science advances · 2026Article
- Ectopic Wnt6 expression induces twin-spot markings in the epidermis of the silkworm Bombyx mori - Potential molecular target to discover evolutionary mechanisms of adaptive body coloration in insects.The FEBS journal · 2026Article
- Decoding color variation: genome-wide characterization and expression analysis of pigment pathways in Neocaridina denticulata.BMC genomics · 2026Article
- DOPA Decarboxylase (DDC) in Pacific Oysters: Characterization and Role in Tyrosine Metabolism and Melanogenesis.Marine biotechnology (New York, N.Y.) · 2025Article
- TheGenes · 2024Article
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- High-resolution silkworm pan-genome provides genetic insights into artificial selection and ecological adaptation.Nature communications · 2022Article
- Tyrosine Hydroxylase and DOPA Decarboxylase Are Associated With Pupal Melanization During Larval-Pupal Transformation inFrontiers in physiology · 2022Article
- Silencing ofFrontiers in physiology · 2022Article
- Enhancement of β-Alanine Biosynthesis inBiology · 2021Article
- Superficially Similar Adaptation Within One Species Exhibits Similar Morphological Specialization but Different Physiological Regulations and Origins.Frontiers in cell and developmental biology · 2020Article
- Role of microsatellites in genetic analysis ofF1000Research · 2019Review
- RNA sequencing reveals differential thermal regulation mechanisms between sexes of Glanville fritillary butterfly in the Tianshan Mountains, China.Molecular biology reports · 2016Article
- Critical Analysis of the Melanogenic Pathway in Insects and Higher Animals.International journal of molecular sciences · 2016Review
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pigmentation pattern of Lepidoptera varies greatly in different development stages. To date, the effects of key genes in the melanin metabolism pathway on larval and adult body color are distinct, yet the effects on pupal pigmentation remains unclear. In the silkworm, Bombyx mori, the black pupa (bp) mutant is only specifically melanized at the pupal stage. Using positional cloning, we found that a mutation in the Aspartate decarboxylase gene (BmADC) is causative in the bp mutant. In the bp mutant, a SINE-like transposon with a length of 493 bp was detected ~2.2 kb upstream of the transcriptional start site of BmADC. This insertion causes a sharp reduction in BmADC transcript levels in bp mutants, leading to deficiency of β-alanine and N-β-alanyl dopamine (NBAD), but accumulation of dopamine. Following injection of β-alanine into bp mutants, the color pattern was reverted that of the wild-type silkworms. Additionally, melanic pupae resulting from knock-down of BmADC in the wild-type strain were obtained. These findings show that BmADC plays a crucial role in melanin metabolism and in the pigmentation pattern of the silkworm pupal stage. Finally, this study contributes to a better understanding of pupa pigmentation patterns in Lepidoptera.
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