ArticleScientific reports2015
Unveiling astrocytic control of cerebral blood flow with optogenetics.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed.
- Impact of multisession 40Hz tACS on hippocampal perfusion in patients with Alzheimer's disease.Alzheimer's research & therapy · 2021Trial
- Substance P regulates Tacr1 neurons, which control nitric oxide-mediated neurovascular coupling in the mouse cortex.Science advances · 2026Article
- Optogenetic Strategies for Motor Recovery After Ischemic Stroke: Mechanisms and Therapeutic Implications.Cellular and molecular neurobiology · 2026Review
- Insulin resistance in cerebral small vessel disease: a mini review.Frontiers in neuroscience · 2026Review
- Characterization of Optimal Optogenetic Stimulation Paradigms to Evoke Calcium Events in Cortical Astrocytes.eNeuro · 2025Article
- Somatostatin-expressing interneurons induce early NO-driven and late specific astrocyte-mediated vasodilation.Nature communications · 2025Article
- Deficiency in N-cadherin-Akt3 signaling impairs the blood-brain barrier.Cell reports · 2025Article
- Neuropsychiatric Manifestations of COVID-19 Disease and Post COVID Syndrome: The Role of N-acetylcysteine and Acetyl-L-carnitine.Current neuropharmacology · 2025Review
- Modeling of Blood Flow Dynamics in Rat Somatosensory Cortex.Biomedicines · 2024Article
- Intermittent Metabolic Switching and Vascular Cognitive Impairment.Journal of obesity & metabolic syndrome · 2024Review
- Analysis of potassium ion diffusion from neurons to capillaries: Effects of astrocyte endfeet geometry.The European journal of neuroscience · 2024Article
- Sex, hormones and cerebrovascular function: from development to disorder.Fluids and barriers of the CNS · 2024Review
- Glymphatic System and Psychiatric Disorders: A Rapid Comprehensive Scoping Review.Current neuropharmacology · 2024Article
- Optoα1AR activation in astrocytes modulates basal hippocampal synaptic excitation and inhibition in a stimulation-specific manner.Hippocampus · 2023Article
- Optogenetic Activation of Astrocytes Reduces Blood-Brain Barrier Disruption via IL-10 In Stroke.Aging and disease · 2023Article
- Astrocytes: new evidence, new models, new roles.Biophysical reviews · 2023Review
- Astrocytic GPCR-Induced CaInternational journal of molecular sciences · 2023Article
- Do astrocytes act as immune cells after pediatric TBI?Neurobiology of disease · 2023Review
- Modeling the relationship between neuronal activity and the BOLD signal: contributions from astrocyte calcium dynamics.Scientific reports · 2023Article
- Modern Microscopic Approaches to Astrocytes.International journal of molecular sciences · 2023Review
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cortical neural activities lead to changes in the cerebral blood flow (CBF), which involves astrocytic control of cerebrovascular tone. However, the manner in which astrocytic activity specifically leads to vasodilation or vasoconstriction is difficult to determine. Here, cortical astrocytes genetically expressing a light-sensitive cation channel, channelrhodopsin-2 (ChR2), were transcranially activated with a blue laser while the spatiotemporal changes in CBF were noninvasively monitored with laser speckle flowgraphy in the anesthetised mouse cortex. A brief photostimulation induced a fast transient increase in CBF. The average response onset time was 0.7 ± 0.7 sec at the activation foci, and this CBF increase spread widely from the irradiation spot with an apparent propagation speed of 0.8-1.1 mm/sec. The broad increase in the CBF could be due to a propagation of diffusible vasoactive signals derived from the stimulated astrocytes. Pharmacological manipulation showed that topical administration of a K(+) channel inhibitor (BaCl2; 0.1-0.5 mM) significantly reduced the photostimulation-induced CBF responses, which indicates that the ChR2-evoked astrocytic activity involves K(+) signalling to the vascular smooth muscle cells. These findings demonstrate a unique model for exploring the role of the astrocytes in gliovascular coupling using non-invasive, time-controlled, cell-type specific perturbations.
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