ArticleJournal of children's orthopaedics2015
Characterization of knee alignment in children with mucopolysaccharidosis types I and II and outcome of treatment with guided growth.
Article in Journal of children's orthopaedics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 23 citations in OpenAlex.
- Relevance of instrumented gait analysis in the prediction of the rebound phenomenon after guided growth intervention.Scientific reports · 2024Article
- Proteomics identifies novel biomarkers of synovial joint disease in a canine model of mucopolysaccharidosis I.Molecular genetics and metabolism · 2023Article
- [Prevalence and predictors of rebound deformity in the frontal plane : A literature review].Der Orthopade · 2021Review
- Treatment of genu valgum in children by means of temporary hemiepiphysiodesis using eight-plates: short-term findings.BMC musculoskeletal disorders · 2017Article
- Does orthopaedic surgery improve quality of life and function in patients with mucopolysaccharidoses?Journal of children's orthopaedics · 2017Article
- Correction of lower limb deformities in children with renal osteodystrophy by guided growth technique.Journal of children's orthopaedics · 2017Article
- Long bone deformity correction and bone lengthening procedures.Journal of children's orthopaedics · 2016Article
- Musculoskeletal manifestations in mucopolysaccharidosis type I (Hurler syndrome) following hematopoietic stem cell transplantation.Orphanet journal of rare diseases · 2016Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo describe knee alignment in children of different ages with severe mucopolysaccharidosis (MPS) I and II and the outcome of treatment with guided growth in a patient subgroup.
methodsThis is a retrospective observational study of 58 knees in 29 children with severe MPS I and II. Long-leg standing radiographs were evaluated to determine mechanical axis deviation, mechanical lateral distal femoral angle and medial proximal tibial angle at different ages throughout childhood. The change in deformity in individual children over time is reported. 20 knees in 10 patients were treated with guided growth using eight-plates. Radiographic measurements were recorded at the time of plate insertion, at plate removal and at 1 year following removal.
resultsAt 8 years of age, all MPS I children and three-quarters of MPS II children had valgus knee alignment. There was deformity progression in two-thirds of MPS I knees and half of MPS II knees. Guided growth corrected the deformities. There was recurrence in most cases 1 year after plate removal.
conclusionsKnee deformity is common in children with severe MPS I and II. Guided growth can be considered where there is significant and/or or progressive deformity with the aim of halting progression and correcting existing deformity and thus minimizing the risk of gross deformity. Patients should be aware of the high rate of recurrence and the need for repeat surgery.
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Registered trials
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