ArticlePloS one2015
Defining the Human Brain Proteome Using Transcriptomics and Antibody-Based Profiling with a Focus on the Cerebral Cortex.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 73 citations in OpenAlex.
- Article
- A comprehensive proteome and phosphoproteome atlas across nine organs of the Chinese hamster.Animal models and experimental medicine · 2026Article
- A Rare Case of Polymicrogyria in an Elderly Individual With Unique Polygenic Underlining.Cureus · 2024Article
- HumanBrainAtlas: an in vivo MRI dataset for detailed segmentations.Brain structure & function · 2023Article
- Robust and rigorous identification of tissue-specific genes by statistically extending tau score.BioData mining · 2022Article
- Genome-wide annotation of protein-coding genes in pig.BMC biology · 2022Article
- Microfluidic device with brain extracellular matrix promotes structural and functional maturation of human brain organoids.Nature communications · 2021Article
- Multi-cohort profiling reveals elevated CSF levels of brain-enriched proteins in Alzheimer's disease.Annals of clinical and translational neurology · 2021Article
- The Impact of High Glucose or Insulin Exposure on S100B Protein Levels, Oxidative and Nitrosative Stress and DNA Damage in Neuron-Like Cells.International journal of molecular sciences · 2021Article
- Fluid proteomics of CSF and serum reveal important neuroinflammatory proteins in blood-brain barrier disruption and outcome prediction following severe traumatic brain injury: a prospective, observational study.Critical care (London, England) · 2021Observational
- The Human Protein Atlas-Spatial localization of the human proteome in health and disease.Protein science : a publication of the Protein Society · 2021Article
- Review
- Using the Gibbs Function as a Measure of Human Brain Development Trends from Fetal Stage to Advanced Age.International journal of molecular sciences · 2020Article
- A Serum Protein Biomarker Panel Improves Outcome Prediction in Human Traumatic Brain Injury.Journal of neurotrauma · 2019Observational
- Proteomic Atlas of the Human Brain in Alzheimer's Disease.Journal of proteome research · 2019Article
- Astrocytes in Neuropathologies Affecting the Frontal Cortex.Frontiers in cellular neuroscience · 2019Review
- Advantages of Structure-Based Drug Design Approaches in Neurological Disorders.Current neuropharmacology · 2017Review
- A review of the clinical utility of serum S100B protein levels in the assessment of traumatic brain injury.Acta neurochirurgica · 2017Review
- Derivation of a Three Biomarker Panel to Improve Diagnosis in Patients with Mild Traumatic Brain Injury.Frontiers in neurology · 2017Article
- Serial Sampling of Serum Protein Biomarkers for Monitoring Human Traumatic Brain Injury Dynamics: A Systematic Review.Frontiers in neurology · 2017Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mammalian brain is a complex organ composed of many specialized cells, harboring sets of both common, widely distributed, as well as specialized and discretely localized proteins. Here we focus on the human brain, utilizing transcriptomics and public available Human Protein Atlas (HPA) data to analyze brain-enriched (frontal cortex) polyadenylated messenger RNA and long non-coding RNA and generate a genome-wide draft of global and cellular expression patterns of the brain. Based on transcriptomics analysis of altogether 27 tissues, we have estimated that approximately 3% (n=571) of all protein coding genes and 13% (n=87) of the long non-coding genes expressed in the human brain are enriched, having at least five times higher expression levels in brain as compared to any of the other analyzed peripheral tissues. Based on gene ontology analysis and detailed annotation using antibody-based tissue micro array analysis of the corresponding proteins, we found the majority of brain-enriched protein coding genes to be expressed in astrocytes, oligodendrocytes or in neurons with molecular properties linked to synaptic transmission and brain development. Detailed analysis of the transcripts and the genetic landscape of brain-enriched coding and non-coding genes revealed brain-enriched splice variants. Several clusters of neighboring brain-enriched genes were also identified, suggesting regulation of gene expression on the chromatin level. This multi-angle approach uncovered the brain-enriched transcriptome and linked genes to cell types and functions, providing novel insights into the molecular foundation of this highly specialized organ.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.