Evidence map›Paper›PMID 26076478›Full record

ArticlePloS one2015

Targeted Lipid Profiling Discovers Plasma Biomarkers of Acute Brain Injury.

Sunil A Sheth, Anthony T Iavarone, David S Liebeskind, Seok Joon Won, Raymond A Swanson

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 63 citations in OpenAlex.

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  10. Molecular profiling of the stroke-induced alterations in the cerebral microvasculature reveals promising therapeutic candidates.Proceedings of the National Academy of Sciences of the United States of America · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Sunil A ShethComprehensive Stroke Center and Department of Neurology, University of California Los Angeles, Los Angeles, California, United States of America.
Anthony T IavaroneQB3/Chemistry Mass Spectrometry Facility, University of California, Berkeley, California, United States of America.
David S LiebeskindComprehensive Stroke Center and Department of Neurology, University of California Los Angeles, Los Angeles, California, United States of America.
Seok Joon WonNeurology and Rehabilitation Service, San Francisco Veterans Affairs Medical Center and Department of Neurology, University of California San Francisco, San Francisco, California, United States of America.
Raymond A SwansonNeurology and Rehabilitation Service, San Francisco Veterans Affairs Medical Center and Department of Neurology, University of California San Francisco, San Francisco, California, United States of America.
University of California, Los Angeles · USUniversity of California, San Francisco · USUniversity of California, Berkeley · US

Funding

Mechanisms of PARP and PARG mediated cell deathR01NS041421 · NINDS · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI SWANSON, RAYMOND A · 2002 to 2014
$2.9M
Regulatory Control of Glutamate - Induced Superoxide Production [Admin Supplement]R01NS081149 · NINDS · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI SWANSON, RAYMOND A · 2012 to 2016
$1.7M
NINDS NIH HHS NS041421NINDS NIH HHS R01 NS041421NINDS NIH HHS R01 NS081149
6 · The paper itself

Abstract

Prior efforts to identify a blood biomarker of brain injury have relied almost exclusively on proteins; however their low levels at early time points and poor correlation with injury severity have been limiting. Lipids, on the other hand, are the most abundant molecules in the brain and readily cross the blood-brain barrier. We previously showed that certain sphingolipid (SL) species are highly specific to the brain. Here we examined the feasibility of using SLs as biomarkers for acute brain injury. A rat model of traumatic brain injury (TBI) and a mouse model of stroke were used to identify candidate SL species though our mass-spectrometry based lipid profiling approach. Plasma samples collected after TBI in the rat showed large increases in many circulating SLs following injury, and larger lesions produced proportionately larger increases. Plasma samples collected 24 hours after stroke in mice similarly revealed a large increase in many SLs. We constructed an SL score (sum of the two SL species showing the largest relative increases in the mouse stroke model) and then evaluated the diagnostic value of this score on a small sample of patients (n = 14) who presented with acute stroke symptoms. Patients with true stroke had significantly higher SL scores than patients found to have non-stroke causes of their symptoms. The SL score correlated with the volume of ischemic brain tissue. These results demonstrate the feasibility of using lipid biomarkers to diagnose brain injury. Future studies will be needed to further characterize the diagnostic utility of this approach and to transition to an assay method applicable to clinical settings.

Indexed as

AnimalsBiomarkersBrain InjuriesBrain IschemiaDisease Models, AnimalFemaleLipid MetabolismLipidsMaleMetabolomicsMiceRatsSphingolipidsStrokeBiomarkersLipidsSphingolipids

Identifiers

PMID26076478
PMCPMC4468135
OpenAlexW572697538

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.