Evidence map›Paper›PMID 26076445›Full record

ArticlePloS one2015

Derivation of Cinnamon Blocks Leukocyte Attachment by Interacting with Sialosides.

Wei-Ling Lin, Shih-Yun Guu, Chan-Chuan Tsai, Ekambaranellore Prakash, Mohan Viswaraman, Hsing-Bao Chen, Chuan-Fa Chang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Wei-Ling LinDepartment of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.
Shih-Yun GuuDepartment of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.
Chan-Chuan TsaiDepartment of Pathology, Pingtung Christian Hospital, Pingtung 900, Taiwan.
Ekambaranellore PrakashIndus Biotech Private Limited, Kondhwa, Pune 411048, India.
Mohan ViswaramanIndus Biotech Private Limited, Kondhwa, Pune 411048, India.
Hsing-Bao ChenDivision of Colorectal Surgery, Department of Surgery, E-DA Hospital, Kaohsiung 82445, Taiwan.
Chuan-Fa ChangDepartment of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan; Center of Infectious Disease and Signaling Research, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan; Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, 1 University Road, Tainan 70101, Taiwan.
National Cheng Kung University · TWIndus Biotech (India) · INE-Da Hospital · TWPingtung Christian Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Molecules derived from cinnamon have demonstrated diverse pharmacological activities against infectious pathogens, diabetes and inflammatory diseases. This study aims to evaluate the effect of the cinnamon-derived molecule IND02 on the adhesion of leukocytes to host cells. The anti-inflammatory ability of IND02, a pentameric procyanidin type A polyphenol polymer isolated from cinnamon alcohol extract, was examined. Pretreatment with IND02 significantly reduced the attachment of THP-1 cells or neutrophils to TNF-α-activated HUVECs or E-selectin/ICAM-1, respectively. IND02 also reduced the binding of E-, L- and P-selectins with sialosides. Furthermore, IND02 could agglutinate human red blood cells (RBC), and the agglutination could be disrupted by sialylated glycoprotein. Our findings demonstrate that IND02, a cinnamon-derived compound, can interact with sialosides and block the binding of selectins and leukocytes with sialic acids.

Indexed as

AgglutinationAnti-Inflammatory AgentsCell AdhesionCell Line, TumorCinnamomum zeylanicumDrugs, Chinese HerbalEndothelium, VascularErythrocyte AggregationErythrocytesE-SelectinHumansHuman Umbilical Vein Endothelial CellsInflammationIntercellular Adhesion Molecule-1N-Acetylneuraminic AcidNeutrophilsAnti-Inflammatory AgentsDrugs, Chinese HerbalE-SelectinIND02 polymerIntercellular Adhesion Molecule-1N-Acetylneuraminic AcidProanthocyanidinsTumor Necrosis Factor-alpha

Identifiers

PMID26076445
PMCPMC4468131
OpenAlexW1518180749

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.